Linkage to markers for the chromosome region 17q12-q21 in 13 Dutch breast cancer kindreds

We have performed linkage analysis with five markers for the chromosome region 17q12-q21 in 13 Dutch breast cancer kindreds in order to find support for the claim by Hall et al. that a gene in this region, termed "BRCA1," is associated with predisposition to early-onset familial breast can...

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Bibliographic Details
Published in:American journal of human genetics 1993-04, Vol.52 (4), p.730-735
Main Authors: Devilee, P, Cornelis, R S, Bootsma, A, Bardoel, A, van Vliet, M, van Leeuwen, I, Cleton, F J, de Klein, A, Lindhout, D, Vasen, H F
Format: Article
Language:English
Subjects:
Adult
BASIC BIOLOGICAL SCIENCES
BODY
breast
Breast Neoplasms - genetics
carcinoma
chromosome 17
Chromosome Mapping - methods
CHROMOSOMES
Chromosomes, Human, Pair 17
DEVELOPED COUNTRIES
DISEASES
DNA HYBRIDIZATION
DNA, Neoplasm - analysis
DNA, Satellite - analysis
EUROPE
Family Health
Female
Genetic Linkage
GENETIC MAPPING
Genetic Markers
GLANDS
HUMAN CHROMOSOME 17
HUMAN CHROMOSOMES
Humans
HYBRIDIZATION
linkage analysis
Lod Score
Male
MAMMARY GLANDS
man
MAPPING
markers
Middle Aged
NEOPLASMS
Neoplastic Syndromes, Hereditary - genetics
NETHERLANDS
ORGANS
Original
Ovarian Neoplasms - genetics
Pedigree
Polymorphism, Restriction Fragment Length
Proto-Oncogenes
RFLPS
WESTERN EUROPE 550400 > Genetics
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Summary:We have performed linkage analysis with five markers for the chromosome region 17q12-q21 in 13 Dutch breast cancer kindreds in order to find support for the claim by Hall et al. that a gene in this region, termed "BRCA1," is associated with predisposition to early-onset familial breast cancer. This work is part of a collaborative study, the results of which are published elsewhere in this issue. Best evidence for linkage was observed with the marker CMM86 (D17S74) in pedigrees with an average age at onset of < or = 47 years (LOD score = 1.77 at 1% recombination). In one breast-ovarian cancer family with a high probability of being linked to 17q, we observed one putative recombinant between D17S250 and D17S579, which suggests that BRCA1 is proximal to D17S579.
ISSN:0002-9297
1537-6605