The cell surface antigen locus, MIC2X, escapes X-inactivation

Recently, it was shown that the cell surface antigen defined by the monoclonal antibody 12E7 is expressed by both the human X and Y chromosomes; the gene loci on the X and Y chromosomes are referred to as MIC2X and MIC2Y, respectively. It was also shown that MIC2X is located in the region Xp22.3---X...

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Bibliographic Details
Published in:American journal of human genetics 1984-07, Vol.36 (4), p.777-782
Main Authors: Goodfellow, P, Pym, B, Mohandas, T, Shapiro, L J
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal
Antigens, Surface - genetics
Chromosome Mapping
Cloning, Molecular
Cricetinae
Dosage Compensation, Genetic
Female
Humans
Hybrid Cells
Male
Mice
Radioimmunoassay
X Chromosome
Y Chromosome
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Summary:Recently, it was shown that the cell surface antigen defined by the monoclonal antibody 12E7 is expressed by both the human X and Y chromosomes; the gene loci on the X and Y chromosomes are referred to as MIC2X and MIC2Y, respectively. It was also shown that MIC2X is located in the region Xp22.3---Xpter and MIC2Y is in the region Ypter-Yq1.1. Here, we show that MIC2X escapes X-inactivation on structurally normal and abnormal inactive human X chromosomes.
ISSN:0002-9297
1537-6605