A genetic study of immunoglobulin E

Path analysis gives evidence of genetic heritability (.425) for serum IgE levels. Complex segregation analysis indicates, in addition to significant polygenic heritability, a major regulatory locus RE, with homozygotes re/re maintaining persistently high levels of IgE. The gene frequency of re is .4...

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Bibliographic Details
Published in:American journal of human genetics 1978-01, Vol.30 (1), p.46-58
Main Authors: Gerrard, J W, Rao, D C, Morton, N E
Format: Article
Language:English
Subjects:
Female
Gene Frequency
Genes
Humans
Hypersensitivity - genetics
Immunoglobulin E - genetics
Male
Statistics as Topic
Online Access:Get full text
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Summary:Path analysis gives evidence of genetic heritability (.425) for serum IgE levels. Complex segregation analysis indicates, in addition to significant polygenic heritability, a major regulatory locus RE, with homozygotes re/re maintaining persistently high levels of IgE. The gene frequency of re is .489, and the displacement is 1.67 standard deviations.
ISSN:0002-9297
1537-6605