PromoSer: a large-scale mammalian promoter and transcription start site identification service

Proximal promoters have a major impact on transcriptional regulation. Studies of the sequence-based nature of this regulation usually require collection of proximal promoter sequences for large sets of co-regulated genes. We report a newly implemented web service that facilitates extraction of user...

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Bibliographic Details
Published in:Nucleic acids research 2003-07, Vol.31 (13), p.3554-3559
Main Authors: Halees, Anason S., Leyfer, Dmitriy, Weng, Zhiping
Format: Article
Language:English
Subjects:
Animals
Genome
Humans
Internet
Mice
Oligonucleotide Array Sequence Analysis
Promoter Regions, Genetic
Rats
RNA, Messenger - chemistry
Sequence Alignment
Sequence Analysis, DNA - methods
Sequence Analysis, RNA - methods
Software
Transcription Initiation Site
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Summary:Proximal promoters have a major impact on transcriptional regulation. Studies of the sequence-based nature of this regulation usually require collection of proximal promoter sequences for large sets of co-regulated genes. We report a newly implemented web service that facilitates extraction of user specified regions around the transcription start site of all annotated human, mouse or rat genes. The transcription start sites have been identified computationally by considering alignments of a large number of partial and full-length mRNA sequences to genomic DNA, with provision for alternative promoters. The service is publicly available at http://biowulf.bu.edu/zlab/PromoSer/.
ISSN:0305-1048
1362-4962
1362-4962
DOI:10.1093/nar/gkg549