Polymeric Coatings That Inactivate Both Influenza Virus and Pathogenic Bacteria

• Published in: Proceedings of the National Academy of Sciences - PNAS 2006-11, Vol.103 (47), p.17667-17671
• Main Authors: Haldar, Jayanta, An, Deqiang, de Cienfuegos, Luis Álvarez, Chen, Jianzhu, Klibanov, Alexander M.
• Format: Article
• Language: English
• Subjects: Animals; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Bacteria; Biological Sciences; Chlorides; Coatings; Correlation analysis; E coli; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - metabolism; Glass; Humans; Influenza; Influenza virus; Leaching; Molecular Structure; Molecular Weight; Orthomyxoviridae; Orthomyxoviridae - drug effects; Orthomyxoviridae - metabolism; Physical Sciences; Polyethylene; Polyethyleneimine - chemistry; Polyethyleneimine - pharmacology; Polymers; Protective coatings; Resultants; Solvents; Staphylococcus aureus; Staphylococcus aureus - drug effects; Staphylococcus aureus - metabolism; Staphylococcus infections; Surface Properties; Viruses
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.0608803103

Painting a glass slide with branched or linear N,N-dodecyl methylpolyethylenimines (PEls) and certain other hydrophobic PEI derivatives enables it to kill influenza virus with essentially a 100% efficiency (at least a 4-log reduction in the viral titer) within minutes, as well as the airborne human pathogenic bacteria Escherichia coil and Staphylococcus aureus. For most of the coating polyions, this virucidal action is shown to be on contact, i.e., solely by the polymeric chains anchored to the slide surface; for others, a contribution of the polyion leaching from the painted surface cannot be ruled out. A relationship between the structure of the derivatized PEI and the resultant virucidal activity of the painted surface has been elucidated.