Neonatal tetanus in Peru: risk assessment with modified enzyme-linked immunosorbent assay and toxoid skin test

We used a modified enzyme-linked immunosorbent assay (ELISA) to investigate tetanus immunity in 232 pregnant Peruvian women. One hundred forty-two (61.2%) had protective antitoxin titers (> or = 0.01 IU/mL). Protective titers correlated positively with the number of toxoid doses reported during t...

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Bibliographic Details
Published in:American journal of public health (1971) 1993-12, Vol.83 (12), p.1754-1756
Main Authors: Vernacchio, L, Madico, G, Verastegui, M, Diaz, F, Collins, T S, Gilman, R H
Format: Article
Language:English
Subjects:
Adult
Bacterial diseases
Bacterial diseases of the nervous system. Bacterial myositis
Biological and medical sciences
Enzyme-Linked Immunosorbent Assay - methods
Enzymes
Evaluation Studies as Topic
Female
Human bacterial diseases
Humans
Immunity (Disease)
Infectious diseases
Linear Models
Mass Screening - methods
Medical research
Medical sciences
Peru - epidemiology
Pregnancy
Pregnancy Complications, Infectious - blood
Pregnancy Complications, Infectious - epidemiology
Pregnancy Complications, Infectious - immunology
Pregnancy Complications, Infectious - prevention & control
Prenatal Care - statistics & numerical data
Public health
Risk Factors
Sensitivity and Specificity
Seroepidemiologic Studies
Skin Tests
Tetanus
Tetanus - blood
Tetanus - epidemiology
Tetanus - immunology
Tetanus - prevention & control
Tetanus Antitoxin - blood
Tetanus Toxoid - administration & dosage
Tetanus Toxoid - therapeutic use
Tropical medicine
Women
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Description
Summary:We used a modified enzyme-linked immunosorbent assay (ELISA) to investigate tetanus immunity in 232 pregnant Peruvian women. One hundred forty-two (61.2%) had protective antitoxin titers (> or = 0.01 IU/mL). Protective titers correlated positively with the number of toxoid doses reported during the current pregnancy. A majority of women reporting no toxoid doses during the current pregnancy had at least one prenatal health care visit. We evaluated a toxoid skin test in 44 of the subjects, but it correlated poorly with the ELISA. The modified ELISA is a useful in vitro method for studying tetanus immunity in the developing world.
ISSN:0090-0036
1541-0048
DOI:10.2105/AJPH.83.12.1754