Susceptibilities of Propionibacterium acnes Ophthalmic Isolates to Ertapenem, Meropenem, and Cefepime

We investigated the in vitro susceptibilities of 23 Propionibacterium acnes ophthalmic isolates to ertapenem, meropenem, and cefepime by utilizing the Etest. The MICs ranged from 0.094 μg/ml to 0.75 μg/ml, 0.094 μg/ml to 1.5 μg/ml, and 1 μg/ml to 12 μg/ml for ertapenem, meropenem, and cefepime, resp...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2006-11, Vol.44 (11), p.4227-4228
Main Authors: Shames, Robert, Satti, Farhana, Vellozzi, Ernestine M, Smith, Miriam A
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Bacteriology
beta-Lactams - pharmacology
Biological and medical sciences
Cephalosporins - pharmacology
Eye - microbiology
Fundamental and applied biological sciences. Psychology
Infectious diseases
Medical sciences
Microbial Sensitivity Tests
Microbiology
Propionibacterium acnes
Propionibacterium acnes - drug effects
Rabbits
Thienamycins - pharmacology
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Summary:We investigated the in vitro susceptibilities of 23 Propionibacterium acnes ophthalmic isolates to ertapenem, meropenem, and cefepime by utilizing the Etest. The MICs ranged from 0.094 μg/ml to 0.75 μg/ml, 0.094 μg/ml to 1.5 μg/ml, and 1 μg/ml to 12 μg/ml for ertapenem, meropenem, and cefepime, respectively. Based on our excellent in vitro carbapenem susceptibility results, in vivo studies using ertapenem and meropenem in a rabbit model of P. acnes endophthalmitis are warranted.
ISSN:0095-1137
1098-660X
1098-5530
DOI:10.1128/JCM.00722-06