Insulin Secretion in Heart Failure

Insulin secretion tests were carried out before and after treatment in patients with severe congestive heart failure. Before treatment the plasma insulin level and the insulin secretion response to intravenous tolbutamide were significantly reduced in all patients. In patients who made a good clinic...

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Bibliographic Details
Published in:BMJ 1970-05, Vol.2 (5706), p.396-398
Main Authors: Sharma, B., Majid, P. A., Pakrashi, B. C., Dykes, J. R. W., Taylor, S. H.
Format: Article
Language:English
Subjects:
Adult
Blood
Blood flow
Blood glucose
Blood Glucose - analysis
Blood plasma
Carbon Dioxide - blood
Female
Heart
Heart Failure - physiopathology
Heart Failure - therapy
Humans
Hydrogen-Ion Concentration
Insulin
Insulin - blood
Insulin - metabolism
Insulin Secretion
Lactates
Male
Medical treatment
Middle Aged
Oxygen - blood
Papers and Originals
Potassium
Tolbutamide
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Summary:Insulin secretion tests were carried out before and after treatment in patients with severe congestive heart failure. Before treatment the plasma insulin level and the insulin secretion response to intravenous tolbutamide were significantly reduced in all patients. In patients who made a good clinical recovery the plasma insulin level and the insulin secretion response were significantly improved. Patients who had a poor response to medical treatment showed little improvement in their insulin secretion test. This suppression of insulin secretion is probably due to the reduced blood flow to the pancreas together with a high level of circulating catecholamines.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.2.5706.396