Insulin Secretion in Heart Failure

Insulin secretion tests were carried out before and after treatment in patients with severe congestive heart failure. Before treatment the plasma insulin level and the insulin secretion response to intravenous tolbutamide were significantly reduced in all patients. In patients who made a good clinic...

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Published in:BMJ 1970-05, Vol.2 (5706), p.396-398
Main Authors: Sharma, B., Majid, P. A., Pakrashi, B. C., Dykes, J. R. W., Taylor, S. H.
Format: Article
Language:English
Subjects:
Adult
Blood
Blood flow
Blood glucose
Blood Glucose - analysis
Blood plasma
Carbon Dioxide - blood
Female
Heart
Heart Failure - physiopathology
Heart Failure - therapy
Humans
Hydrogen-Ion Concentration
Insulin
Insulin - blood
Insulin - metabolism
Insulin Secretion
Lactates
Male
Medical treatment
Middle Aged
Oxygen - blood
Papers and Originals
Potassium
Tolbutamide
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cited_by cdi_FETCH-LOGICAL-b507t-c8d8f7ebebd2ab0d8c85b4acea92d21c0e0ec87a51c47b6f3e7d1017edf949883
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container_end_page 398
container_issue 5706
container_start_page 396
container_title BMJ
container_volume 2
creator Sharma, B.
Majid, P. A.
Pakrashi, B. C.
Dykes, J. R. W.
Taylor, S. H.
description Insulin secretion tests were carried out before and after treatment in patients with severe congestive heart failure. Before treatment the plasma insulin level and the insulin secretion response to intravenous tolbutamide were significantly reduced in all patients. In patients who made a good clinical recovery the plasma insulin level and the insulin secretion response were significantly improved. Patients who had a poor response to medical treatment showed little improvement in their insulin secretion test. This suppression of insulin secretion is probably due to the reduced blood flow to the pancreas together with a high level of circulating catecholamines.
doi_str_mv 10.1136/bmj.2.5706.396
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This suppression of insulin secretion is probably due to the reduced blood flow to the pancreas together with a high level of circulating catecholamines.</description><identifier>ISSN: 0007-1447</identifier><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1468-5833</identifier><identifier>DOI: 10.1136/bmj.2.5706.396</identifier><identifier>PMID: 5420607</identifier><language>eng</language><publisher>England: British Medical Journal Publishing Group</publisher><subject>Adult ; Blood ; Blood flow ; Blood glucose ; Blood Glucose - analysis ; Blood plasma ; Carbon Dioxide - blood ; Female ; Heart ; Heart Failure - physiopathology ; Heart Failure - therapy ; Humans ; Hydrogen-Ion Concentration ; Insulin ; Insulin - blood ; Insulin - metabolism ; Insulin Secretion ; Lactates ; Male ; Medical treatment ; Middle Aged ; Oxygen - blood ; Papers and Originals ; Potassium ; Tolbutamide</subject><ispartof>BMJ, 1970-05, Vol.2 (5706), p.396-398</ispartof><rights>Copyright 1970 British Medical Journal</rights><rights>Copyright BMJ Publishing Group LTD May 16, 1970</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b507t-c8d8f7ebebd2ab0d8c85b4acea92d21c0e0ec87a51c47b6f3e7d1017edf949883</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1700297/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1700297/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,3181,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5420607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharma, B.</creatorcontrib><creatorcontrib>Majid, P. 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0959-8138
1468-5833
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source BMJ; PubMed Central
subjects Adult
Blood
Blood flow
Blood glucose
Blood Glucose - analysis
Blood plasma
Carbon Dioxide - blood
Female
Heart
Heart Failure - physiopathology
Heart Failure - therapy
Humans
Hydrogen-Ion Concentration
Insulin
Insulin - blood
Insulin - metabolism
Insulin Secretion
Lactates
Male
Medical treatment
Middle Aged
Oxygen - blood
Papers and Originals
Potassium
Tolbutamide
title Insulin Secretion in Heart Failure
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