Serum Creatine Phosphokinase Levels in Pigs Reacting Abnormally to Halogenated Anaesthetics

Serum levels of creatine phosphokinase (CPK) were estimated in pigs. Among those known to react abnormally either to halothane alone or to halothane and suxamethonium most had very high levels of CPK. Twenty-four hours after five minutes' anaesthesia with halothane and oxygen a sustained, prono...

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Bibliographic Details
Published in:BMJ 1970-08, Vol.3 (5719), p.386-387
Main Authors: Woolf, Neville, Hall, Leslie, Thorne, Christopher, Down, Margaret, Walker, Robert
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesia, Inhalation - adverse effects
Animals
Creatine
Creatine Kinase - blood
Enzymes
Fever - chemically induced
Halothane - adverse effects
Humans
Medical journals
Muscles
Oxygen
Preliminary Communications
Succinylcholine
Swine
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Summary:Serum levels of creatine phosphokinase (CPK) were estimated in pigs. Among those known to react abnormally either to halothane alone or to halothane and suxamethonium most had very high levels of CPK. Twenty-four hours after five minutes' anaesthesia with halothane and oxygen a sustained, pronounced rise in the serum CPK occurred in some pigs—principally but not exclusively in the abnormal reactors. Estimation of the serum level of CPK may be a useful screening test for an abnormal hyperpyrexial response to halothane.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.3.5719.386