Modification of the vasoconstrictor action of sympathomimetic agents by bretylium tosylate and tranylcypromine in man

1 The vasoconstrictor actions of tyramine, methylamphetamine and ephedrine on the blood vessels of the human hand have been found to be potentiated by administration intra‐arterially of the adrenergic neurone blocking agent, bretylium tosylate. 2 One mechanism suggested for the enhancement of vasoco...

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Bibliographic Details
Published in:British journal of pharmacology 1969-07, Vol.36 (3), p.602-610
Main Authors: FREWIN, D. B., JELLETT, L. B., WHELAN, R. F.
Format: Article
Language:English
Subjects:
Bretylium Compounds - pharmacology
Ephedrine - pharmacology
Hand - blood supply
Humans
Injections, Intra-Arterial
Methamphetamine - pharmacology
Plethysmography
Regional Blood Flow - drug effects
Sympathomimetics - pharmacology
Tranylcypromine - pharmacology
Tyramine - pharmacology
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Summary:1 The vasoconstrictor actions of tyramine, methylamphetamine and ephedrine on the blood vessels of the human hand have been found to be potentiated by administration intra‐arterially of the adrenergic neurone blocking agent, bretylium tosylate. 2 One mechanism suggested for the enhancement of vasoconstriction is that bretylium possesses monoamine oxidase inhibitilng activity, which, in the case of tyramine, is protective both to the sympathomimetic agent and the intraneuronal transmitter which it releases. In the case of methylamphetamine and ephedrine, which are not substrates for the enzyme, protection of the intraneuronal transmitter alone might occur, accounting for the lesser degree of potentiation of the effect of these amines by bretylium. 3 Comparison of the influences of bretylium and the monoamine oxidase inhibitor, tranylcypromine, on the vasoconstrictor action of the sympathomimetic agents shows a similar pattern of enhancement in the presence of both these drugs. 4 Tranylcypromine caused enhancement of the response of the hand vessels to noradrenaline, and this action could contribute to its potentiation of the effect of the sympathomimetic amines. 5 For a monoamine oxidase inhibiting action of bretylium to be effective in potentiating the constrictor actions of the sympathomimetic agents on the hand blood vessels at a time when reflex sympathetic activity is blocked it is necessary to postulate that these drugs and reflex nerve activity act either on different compartments of the transmitter store or by different release mechanisms.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1969.tb08015.x