THE DEMONSTRATION OF THE SITE OF ACTION OF THE ANTIMETABOLITE DRUG 6‐AZAURIDINE BY THE USE OF LEUCOCYTE CULTURES

The ability of the lymphocyte cultured in vitro to transform and synthesize deoxyribonucleic has been utilized to locate the site of action of a new antimetabolite 6‐azauridine which acts by inhibiting nucleic acid synthesis. The exact site can be demonstrated by incorporating into the cultures nucl...

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Bibliographic Details
Published in:British Journal of Pharmacology and Chemotherapy 1964-08, Vol.23 (1), p.90-92
Main Authors: BUTTOO, A. S., ELVES, M. W., ISRAËLS, M. C. G., ROATH, O. S.
Format: Article
Language:English
Subjects:
Antimetabolites
Azauridine
DNA
Leukocytes
Metabolism
Nucleic Acids
Nucleotides
Orotic Acid
Pharmacology
Pyrimidines
Uracil Nucleotides
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Summary:The ability of the lymphocyte cultured in vitro to transform and synthesize deoxyribonucleic has been utilized to locate the site of action of a new antimetabolite 6‐azauridine which acts by inhibiting nucleic acid synthesis. The exact site can be demonstrated by incorporating into the cultures nucleotides occurring distal and proximal to the presumed site of action of 6‐azauridine.
ISSN:0366-0826
1476-5381
DOI:10.1111/j.1476-5381.1964.tb01569.x