Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q

Glaucoma is the third-leading cause of blindness in the world, affecting >13.5 million people. Adult-onset primary open-angle glaucoma (POAG) is the most common form of glaucoma in the United States. We present a family in which adult-onset POAG is inherited as an autosomal dominant trait. Twelve...

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Bibliographic Details
Published in:American journal of human genetics 1997-02, Vol.60 (2), p.296-304
Main Authors: WIRTZ, M. K, SAMPLES, J. R, KRAMER, P. L, RUST, K, TOPINKA, J. R, YOUNT, J, KOLER, R. D, ACOTT, T. S
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Chromosome Mapping
Chromosomes, Human, Pair 3
Female
Genes, Dominant
Genetic Linkage
Glaucoma and intraocular pressure
Glaucoma, Open-Angle - genetics
Humans
Male
Medical sciences
Microsatellite Repeats
Middle Aged
Ophthalmology
Pedigree
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Summary:Glaucoma is the third-leading cause of blindness in the world, affecting >13.5 million people. Adult-onset primary open-angle glaucoma (POAG) is the most common form of glaucoma in the United States. We present a family in which adult-onset POAG is inherited as an autosomal dominant trait. Twelve affected family members were identified from 44 at-risk individuals. The disease-causing gene was mapped to chromosome 3q21-24, with analysis of recombinant haplotypes suggesting a total inclusion region of 11.1 cM between markers D3S3637 and D3S1744. This is the first report of mapping of an adult-onset POAG gene to chromosome 3q, gene symbol GLC1C.
ISSN:0002-9297
1537-6605