5-Aminolevulinate synthase is at 3p21 and thus not the primary defect in X-linked sideroblastic anemia

The gene for 5-aminolevulinate synthase (ALAS) has been mapped to 3pter-3q13.2 by Southern blot hybridization analysis of a mouse/human hybrid cell panel. In situ hybridization maps the gene to 3p21, distal to the common fragile site at 3p14.2 (FRA3B). The mapping of this gene to an autosome makes i...

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Bibliographic Details
Published in:American journal of human genetics 1988-09, Vol.43 (3), p.331-335
Main Authors: SUTHERLAND, G. R, BAKER, E, CALLEN, D. F, HYLAND, V. J, MAY, B. K, BAWDEN, M. J, HEALY, H. M, BORTHWICK, I. A
Format: Article
Language:English
Subjects:
5-Aminolevulinate Synthetase - genetics
Anemia, Sideroblastic - genetics
Anemias. Hemoglobinopathies
Biological and medical sciences
Chromosome Mapping
Chromosomes, Human, Pair 3
Cloning, Molecular
Defects
Diseases of red blood cells
Hematologic and hematopoietic diseases
Humans
Medical sciences
Nucleic Acid Hybridization
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Summary:The gene for 5-aminolevulinate synthase (ALAS) has been mapped to 3pter-3q13.2 by Southern blot hybridization analysis of a mouse/human hybrid cell panel. In situ hybridization maps the gene to 3p21, distal to the common fragile site at 3p14.2 (FRA3B). The mapping of this gene to an autosome makes it improbable that it is the site of the primary defect in X-linked sideroblastic anemia.
ISSN:0002-9297
1537-6605