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5-Aminolevulinate synthase is at 3p21 and thus not the primary defect in X-linked sideroblastic anemia

The gene for 5-aminolevulinate synthase (ALAS) has been mapped to 3pter-3q13.2 by Southern blot hybridization analysis of a mouse/human hybrid cell panel. In situ hybridization maps the gene to 3p21, distal to the common fragile site at 3p14.2 (FRA3B). The mapping of this gene to an autosome makes i...

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Published in:	American journal of human genetics 1988-09, Vol.43 (3), p.331-335
Main Authors:	SUTHERLAND, G. R, BAKER, E, CALLEN, D. F, HYLAND, V. J, MAY, B. K, BAWDEN, M. J, HEALY, H. M, BORTHWICK, I. A
Format:	Article
Language:	English
Subjects:	5-Aminolevulinate Synthetase - genetics Anemia, Sideroblastic - genetics Anemias. Hemoglobinopathies Biological and medical sciences Chromosome Mapping Chromosomes, Human, Pair 3 Cloning, Molecular Defects Diseases of red blood cells Hematologic and hematopoietic diseases Humans Medical sciences Nucleic Acid Hybridization
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container_title	American journal of human genetics
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creator	SUTHERLAND, G. R BAKER, E CALLEN, D. F HYLAND, V. J MAY, B. K BAWDEN, M. J HEALY, H. M BORTHWICK, I. A
description	The gene for 5-aminolevulinate synthase (ALAS) has been mapped to 3pter-3q13.2 by Southern blot hybridization analysis of a mouse/human hybrid cell panel. In situ hybridization maps the gene to 3p21, distal to the common fragile site at 3p14.2 (FRA3B). The mapping of this gene to an autosome makes it improbable that it is the site of the primary defect in X-linked sideroblastic anemia.
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source	International Bibliography of the Social Sciences (IBSS); PubMed Central
subjects	5-Aminolevulinate Synthetase - genetics Anemia, Sideroblastic - genetics Anemias. Hemoglobinopathies Biological and medical sciences Chromosome Mapping Chromosomes, Human, Pair 3 Cloning, Molecular Defects Diseases of red blood cells Hematologic and hematopoietic diseases Humans Medical sciences Nucleic Acid Hybridization
title	5-Aminolevulinate synthase is at 3p21 and thus not the primary defect in X-linked sideroblastic anemia
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