Status epilepticus: pathophysiology, epidemiology, and outcomes

Inhibitory neurotransmitters such as GABA later increase at the seizure focus and redress the balance between excitation and inhibition. 6 GABA also increases in the substantia nigra pars reticulata, an area that can modulate a cortical inhibitory response in adult rats, but not in immature rats. 3...

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Bibliographic Details
Published in:Archives of disease in childhood 1998-07, Vol.79 (1), p.73-77
Main Authors: Scott, Rod C, Surtees, Robert A H, Neville, Brian G R
Format: Article
Language:English
Subjects:
Adults
Age
Animals
Biological and medical sciences
Brain
Brain - metabolism
Brain - physiopathology
Child
Child, Preschool
Children & youth
Convulsions & seizures
Current Topic
Electrolytes
Electrophysiology
Epidemiology
Epilepsy
gamma-Aminobutyric Acid - metabolism
Glucose
Glutamic Acid - metabolism
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Homeostasis
Humans
Incidence
Inhibition
Medical sciences
Morbidity
Mortality
Narcotics
Nervous system (semeiology, syndromes)
Neurological Impairments
Neurology
Patients
Prognosis
Rats
Rodents
Seizures
Status Epilepticus - epidemiology
Status Epilepticus - etiology
Status Epilepticus - therapy
Treatment Outcome
Citations: Items that cite this one
Online Access:Get full text
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Description
Summary:Inhibitory neurotransmitters such as GABA later increase at the seizure focus and redress the balance between excitation and inhibition. 6 GABA also increases in the substantia nigra pars reticulata, an area that can modulate a cortical inhibitory response in adult rats, but not in immature rats. 3 Other mechanisms of inhibitory receptor modulation, such as adenosine receptor agonism, may also contribute to seizure termination. [...]the increased incidence of CSE in childhood is probably caused by a combination of increased seizure susceptibility and decreased ability to mount an adequate inhibitory response. [...]these studies do not address the question of whether mesial temporal damage which is not epileptogenic, may cause cognitive, especially memory, impairment.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.79.1.73