Failure of IGF-I and IGFBP-3 to diagnose growth hormone insufficiency

BACKGROUND Growth hormone insufficiency (GHI) is diagnosed conventionally by short stature and slow growth, and is confirmed by diminished peak GH response to a provocation test. Insulin-like growth factor I (IGF-I) and IGF binding protein 3 (IGFBP-3) have previously been considered individually OBJ...

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Bibliographic Details
Published in:Archives of disease in childhood 1999-05, Vol.80 (5), p.443-447
Main Authors: Mitchell, H, Dattani, M T, Nanduri, V, Hindmarsh, P C, Preece, M A, Brook, C G D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Biological and medical sciences
Biomarkers - blood
Body Height
Child
Child, Preschool
Children & youth
Endocrinology
Female
Females
Growth Disorders - diagnosis
growth hormone insufficiency
Growth hormones
Human Growth Hormone - deficiency
Humans
Immunoassay
Infant
Influence
Insulin
insulin-like growth factor binding protein 3
Insulin-Like Growth Factor Binding Protein 3 - blood
insulin-like growth factor I
Insulin-Like Growth Factor I - metabolism
Insulin-like growth factors
Investigative techniques, diagnostic techniques (general aspects)
Male
Males
Maximum Likelihood Statistics
Measurement Techniques
Medical research
Medical sciences
Middle Aged
Molecular weight
Nutrition
Original
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Patients
Physical growth
Reference Values
Retrospective Studies
Sensitivity and Specificity
Statistical analysis
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Summary:BACKGROUND Growth hormone insufficiency (GHI) is diagnosed conventionally by short stature and slow growth, and is confirmed by diminished peak GH response to a provocation test. Insulin-like growth factor I (IGF-I) and IGF binding protein 3 (IGFBP-3) have previously been considered individually OBJECTIVE To test the hypothesis that the combined analysis of IGF-I and IGFBP-3 could act as a surrogate marker for the diagnosis of GHI. DESIGN Reference ranges for IGF-I and IGFBP-3 were calculated using 521 normal individuals. A retrospective analysis was performed on 318 children referred for investigation of short stature. RESULTS No significant difference was found between either the IGF-I or IGFBP-3 standard deviation scores (SDSs) in children with and without GHI. If the requirement were for both tests to be positive (
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.80.5.443