Investigation of hypertension and the recognition of monogenic hypertension

A family history of severe hypertension, especially with onset in adolescence or early adulthood, is suggestive of one of the dominantly inherited conditions, whereas consanguinity predisposes to the recessive types. Because plasma aldosterone concentrations are not always suppressed, blood should b...

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Bibliographic Details
Published in:Archives of disease in childhood 1999-11, Vol.81 (5), p.452-455
Main Author: Milford, David V
Format: Article
Language:English
Subjects:
Adults
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Body Weight
Cardiology. Vascular system
Child
Child Health
Child, Preschool
Chromosomes
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Current Topic
Dehydrogenases
Electrolytes
Enzymes
Family (Sociological Unit)
Family medical history
Genetic Predisposition to Disease - genetics
Genetics
Humans
Hypertension
Hypertension - drug therapy
Hypertension - etiology
Hypertension - genetics
Kidney diseases
Laboratories
Medical Evaluation
Medical sciences
Metabolites
Mineralocorticoids - physiology
Mutation
Physical Examinations
Physiology
Plasma
Potassium
Preschool Children
Retention
Sampling
Scientific Concepts
Sodium
Sodium - metabolism
Urine
Water
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Description
Summary:A family history of severe hypertension, especially with onset in adolescence or early adulthood, is suggestive of one of the dominantly inherited conditions, whereas consanguinity predisposes to the recessive types. Because plasma aldosterone concentrations are not always suppressed, blood should be taken for angiotensin II measurement at the time of sampling for renin. Because plasma cortisol concentrations are several orders of magnitude higher than aldosterone and the mineralocorticoid receptor binds aldosterone and cortisol equally, a mechanism exists to protect the mineralocorticoid receptor by metabolising cortisol to cortisone in mineralocorticoid target tissues.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.81.5.452