Helicobacter pylori infection with iron deficiency anaemia and subnormal growth at puberty

• Published in: Archives of disease in childhood 2000-02, Vol.82 (2), p.136-140
• Main Authors: Choe, Yon Ho, Kim, Soon Ki, Hong, Yun Chul
• Format: Article
• Language: English
• Subjects: Adolescent; adolescents; Age Differences; Analysis of Variance; Anemia, Iron-Deficiency - blood; Anemia, Iron-Deficiency - complications; Anemias. Hemoglobinopathies; Biological and medical sciences; Body Height; Body Weight; Child; Children; Children & youth; Confidence intervals; Crowding; Diseases of red blood cells; Elementary Education; Elementary Schools; Environmental Influences; Female; Females; General and Specialist Paediatrics; growth deficit; Growth Disorders - blood; Growth Disorders - etiology; Growth Disorders - microbiology; Helicobacter Infections - blood; Helicobacter Infections - complications; Helicobacter pylori; Hematologic and hematopoietic diseases; Hemorrhage; Humans; Infections; Iron; iron deficiency anaemia; Laboratories; Male; Medical sciences; Nutrient deficiency; Parents; Puberty; Regression Analysis; Risk Factors; Socioeconomics; Studies; Ulcers
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/adc.82.2.136

The purpose of this study was to determine whetherHelicobacter pylori infection can contribute to growth deficit, especially in pubescent children who need large amounts of iron for growth. A structured questionnaire was sent to the parents of 532 healthy children aged 10 to 15 years (mean 12.9) to obtain demographic information on the parents and the environment. Of the 532 questionnaires sent out, 375 (70.5%; 170 girls and 205 boys) were returned. After collecting blood samples from participants, haemoglobin, serum iron, total iron binding capacity, serum ferritin, and serum IgG antibodies to H pylori were measured. The effects of risk factors such as H pylori infection, iron deficiency anaemia, sex, socioeconomic status, type of house, and crowding index on growth were analysed using multiple regression analysis. Of 63 H pyloripositive children, 18 (28.6%) were below the 25th centile values for height, compared with 63 of 312 (20.2%) H pylori negative children. The prevalence rate ofH pylori infection was 15.5% (53 of 343) in children without iron deficiency anaemia and 31.3% (10 of 32) in those affected. The relative risk of short stature was 2.2 (95% confidence interval (CI), 1.0 to 4.8) for iron deficiency anaemia, and 1.4 (95% CI, 0.8 to 2.4) for H pylori infection. The mean height was significantly lower in the group having bothH pylori infection and iron deficiency anaemia. Therefore, H pylori infection accompanied by iron deficiency anaemia, rather thanH pylori infection per se, might delay pubertal growth.