Relation of arterial stiffness with gestational age and birth weight

Background: The cardiovascular risk of individuals who are born small as a result of prematurity remains controversial. Given the previous findings of stiffer peripheral conduit arteries in growth restricted donor twins in twin–twin transfusion syndrome regardless of gestational age, we hypothesised...

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Bibliographic Details
Published in:Archives of disease in childhood 2004-03, Vol.89 (3), p.217-221
Main Authors: Cheung, Y F, Wong, K Y, Lam, Barbara C C, Tsoi, N S
Format: Article
Language:English
Subjects:
Arteries
Biological and medical sciences
Birth Weight - physiology
Blood Flow Velocity - physiology
blood pressure
Blood Pressure - physiology
Blood vessels
Body Weight - physiology
Brachial Artery - physiology
Cardiovascular diseases
Care and treatment
Child
Children
Elasticity
Female
Fetal Growth Retardation - physiopathology
General aspects
Gestational Age
Health aspects
Humans
Infant, Newborn
Infant, Premature - physiology
Infant, Small for Gestational Age - physiology
Male
Medical sciences
Original
Pulsatile Flow - physiology
pulse wave velocity
PWV
Radial Artery - physiology
SGA
small for gestational age
Vascular Resistance - physiology
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Summary:Background: The cardiovascular risk of individuals who are born small as a result of prematurity remains controversial. Given the previous findings of stiffer peripheral conduit arteries in growth restricted donor twins in twin–twin transfusion syndrome regardless of gestational age, we hypothesised that among children born preterm, only those with intrauterine growth retardation are predisposed to an increase in cardiovascular risks. Aim: To compare brachioradial arterial stiffness and systemic blood pressure (BP) among children born preterm and small for gestational age (group 1, n = 15), those born preterm but having birth weight appropriate for gestational age (group 2, n = 36), and those born at term with birth weight appropriate for gestational age (group 3, n = 35). Methods: Systemic BP was measured by an automated device (Dinamap), while stiffness of the brachioradial arterial segment was assessed by measuring pulse wave velocity (PWV). The birth weight was adjusted for gestational age and expressed as a z score for analysis. Results: The 86 children were studied at a mean (SD) age of 8.2 (1.7) years. Subjects from group 1, who were born at 32.3 (2.0) weeks’ gestation had a significantly lower z score of birth weight (−2.29 (0.63), p
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.2003.025999