First UK survey of paediatric type 2 diabetes and MODY

• Published in: Archives of disease in childhood 2004-06, Vol.89 (6), p.526-529
• Main Authors: Ehtisham, S, Hattersley, A T, Dunger, D B, Barrett, T G
• Format: Article
• Language: English
• Subjects: Adolescent; Analysis. Health state; Biological and medical sciences; Body Composition; Child; Childhood obesity; Comparative analysis; Consultants; Cross-Sectional Studies; Data Collection; Diabetes; diabetes mellitus; Diabetes Mellitus - epidemiology; Diabetes Mellitus, Type 2 - epidemiology; Epidemiology; Ethnic Groups; Ethnicity; Female; General aspects; Guidelines; Health Surveys; Humans; Insulin resistance; Longitudinal Studies; Male; Medical sciences; Minority & ethnic groups; Minority Groups; MODY; Mutation; Obesity; Obesity in children; Original; Patients; Puberty; Public health. Hygiene; Public health. Hygiene-occupational medicine; Questionnaires; Risk Factors; Risk factors (Health); Studies; Surveys and Questionnaires; Type 1 diabetes; Type 2 diabetes; United Kingdom - epidemiology
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/adc.2003.027821

Aims: To estimate the UK prevalence of childhood type 2 diabetes and maturity onset diabetes of the young (MODY), and distinguish them from each other and from type 1 diabetes. Methods: The British Society for Paediatric Endocrinology and Diabetes Clinical Trials/Audit Group undertook a cross-sectional questionnaire survey of all paediatric diabetes centres during 2000, collecting data on all children with non-type 1 diabetes. Results: Of 112 children reported to the survey, 25 had type 2 diabetes and 20 had MODY. In contrast to type 1, type 2 patients presented later (12.8 v 9.3 years), were usually female, overweight, or obese (92% v 28%), and a greater proportion were of ethnic minority origin (56% v 22%). In contrast to type 2, MODY patients were younger (10.8 years), less likely to be overweight or obese (50% v 92%), and none were from ethnic minority groups. The crude minimum UK prevalence of type 2 diabetes under 16 years is 0.21/100 000, and of MODY is 0.17/100 000. South Asian children have a relative risk of type 2 diabetes of 13.7 compared to white UK children. Conclusions: UK children still have a low prevalence of type 2 diabetes. Children from ethnic minorities are at significantly higher risk, but in white UK children with non-type 1 diabetes a diagnosis of MODY is as likely as type 2 diabetes. Childhood type 2 diabetes is characterised by insulin resistance, and is distinct from both type 1 and MODY.