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Neurobehaviour of school age children born to diabetic mothers
AIM To study the neurobehavioural effects that diabetes during pregnancy might have on children by school age. METHODS The neurobehavioural function of 57 school age children born to 48, well controlled diabetic mothers was compared with 57 control children matched for age, birth order, and parental...
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Published in: | Archives of disease in childhood. Fetal and neonatal edition 1998-09, Vol.79 (2), p.F94-F99 |
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creator | Ornoy, A Ratzon, N Greenbaum, C Peretz, E Soriano, D Dulitzky, M |
description | AIM To study the neurobehavioural effects that diabetes during pregnancy might have on children by school age. METHODS The neurobehavioural function of 57 school age children born to 48, well controlled diabetic mothers was compared with 57 control children matched for age, birth order, and parental socioeconomic status, using several cognitive, behavioural, sensory and motor neurological tests. RESULTS The IQ scores of the index group children were similar to those of control children (117.7±13.4 vs118.5±10.1). There were no differences between the groups in various sensory motor functions. However, the index group children performed less well than the controls on indices of fine and gross motor functions, as observed on the Bruininks–Oseretzky test of motor proficiency. The scores of children born to diabetic mothers were higher than controls on the Touwen and Prechtl neurological examination. They also performed worse in the Pollack tapper test which is designed to detect minor neurological deficits, inattention, and hyperactivity. The index children had higher scores on the Conners abbreviated parent–teacher questionnaire which measures hyperactivity and inattention. There was a negative correlation between the performance of the index group children on various neurodevelopmental and behavioural tests and the severity of hyperglycaemia, as assessed by blood glycosylated haemoglobin and acetonuria. CONCLUSIONS Diabetes during pregnancy adversely affects some fine neurological functions in children at school age, but not their cognitive scores. These effects are not correlated with the degree of glycaemic control. |
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METHODS The neurobehavioural function of 57 school age children born to 48, well controlled diabetic mothers was compared with 57 control children matched for age, birth order, and parental socioeconomic status, using several cognitive, behavioural, sensory and motor neurological tests. RESULTS The IQ scores of the index group children were similar to those of control children (117.7±13.4 vs118.5±10.1). There were no differences between the groups in various sensory motor functions. However, the index group children performed less well than the controls on indices of fine and gross motor functions, as observed on the Bruininks–Oseretzky test of motor proficiency. The scores of children born to diabetic mothers were higher than controls on the Touwen and Prechtl neurological examination. They also performed worse in the Pollack tapper test which is designed to detect minor neurological deficits, inattention, and hyperactivity. The index children had higher scores on the Conners abbreviated parent–teacher questionnaire which measures hyperactivity and inattention. There was a negative correlation between the performance of the index group children on various neurodevelopmental and behavioural tests and the severity of hyperglycaemia, as assessed by blood glycosylated haemoglobin and acetonuria. CONCLUSIONS Diabetes during pregnancy adversely affects some fine neurological functions in children at school age, but not their cognitive scores. These effects are not correlated with the degree of glycaemic control.</description><identifier>ISSN: 1359-2998</identifier><identifier>EISSN: 1468-2052</identifier><identifier>DOI: 10.1136/fn.79.2.F94</identifier><identifier>PMID: 9828733</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Age ; Associated diseases and complications ; Attention deficit hyperactivity disorder ; Biological and medical sciences ; Birth weight ; Child ; Children & youth ; Cognition Disorders - etiology ; Congenital diseases ; Diabetes ; Diabetes. Impaired glucose tolerance ; Education ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Follow-Up Studies ; Hospitals ; Humans ; Hyperactivity ; Intelligence Tests ; Male ; Medical sciences ; Metabolism ; Motor Skills ; Motor Skills Disorders - etiology ; neurological functions ; Newborn babies ; Original ; Pregnancy ; Pregnancy in Diabetics ; Prenatal Exposure Delayed Effects ; school age children ; Socioeconomics ; Womens health</subject><ispartof>Archives of disease in childhood. Fetal and neonatal edition, 1998-09, Vol.79 (2), p.F94-F99</ispartof><rights>Royal College of Paediatrics and Child Health</rights><rights>1998 INIST-CNRS</rights><rights>Copyright: 1998 Royal College of Paediatrics and Child Health</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b610t-3280382c19fa319a64f19c3ccd0e533b96d6a8c032f7356da59d56d9c4b058b53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1720831/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1720831/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2362815$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9828733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ornoy, A</creatorcontrib><creatorcontrib>Ratzon, N</creatorcontrib><creatorcontrib>Greenbaum, C</creatorcontrib><creatorcontrib>Peretz, E</creatorcontrib><creatorcontrib>Soriano, D</creatorcontrib><creatorcontrib>Dulitzky, M</creatorcontrib><title>Neurobehaviour of school age children born to diabetic mothers</title><title>Archives of disease in childhood. Fetal and neonatal edition</title><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><description>AIM To study the neurobehavioural effects that diabetes during pregnancy might have on children by school age. METHODS The neurobehavioural function of 57 school age children born to 48, well controlled diabetic mothers was compared with 57 control children matched for age, birth order, and parental socioeconomic status, using several cognitive, behavioural, sensory and motor neurological tests. RESULTS The IQ scores of the index group children were similar to those of control children (117.7±13.4 vs118.5±10.1). There were no differences between the groups in various sensory motor functions. However, the index group children performed less well than the controls on indices of fine and gross motor functions, as observed on the Bruininks–Oseretzky test of motor proficiency. The scores of children born to diabetic mothers were higher than controls on the Touwen and Prechtl neurological examination. They also performed worse in the Pollack tapper test which is designed to detect minor neurological deficits, inattention, and hyperactivity. The index children had higher scores on the Conners abbreviated parent–teacher questionnaire which measures hyperactivity and inattention. There was a negative correlation between the performance of the index group children on various neurodevelopmental and behavioural tests and the severity of hyperglycaemia, as assessed by blood glycosylated haemoglobin and acetonuria. CONCLUSIONS Diabetes during pregnancy adversely affects some fine neurological functions in children at school age, but not their cognitive scores. These effects are not correlated with the degree of glycaemic control.</description><subject>Age</subject><subject>Associated diseases and complications</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Biological and medical sciences</subject><subject>Birth weight</subject><subject>Child</subject><subject>Children & youth</subject><subject>Cognition Disorders - etiology</subject><subject>Congenital diseases</subject><subject>Diabetes</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Education</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hyperactivity</subject><subject>Intelligence Tests</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Motor Skills</subject><subject>Motor Skills Disorders - etiology</subject><subject>neurological functions</subject><subject>Newborn babies</subject><subject>Original</subject><subject>Pregnancy</subject><subject>Pregnancy in Diabetics</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>school age children</subject><subject>Socioeconomics</subject><subject>Womens health</subject><issn>1359-2998</issn><issn>1468-2052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNp9kc1rFTEUxYMotX26ci0MKG5knvmYfG0K8rAq1LrRCm5Ckkk6ec4kbTJT6n9vyns8PxZC4AbOj8O59wDwDME1QoS98XHN5Rqvz2T3AByjjokWQ4of1j-hssVSisfgpJQthBBxzo_AkRRYcEKOwemFW3IybtC3IS25Sb4pdkhpbPSVa-wQxj672JiUYzOnpg_auDnYZkrz4HJ5Ah55PRb3dD9X4OvZuy-bD-355_cfN2_PW8MQnFuCBSQCWyS9Jkhq1nkkLbG2h44SYiTrmRYWEuw5oazXVPZ1SNsZSIWhZAVOd77Xi5lcb12csx7VdQ6Tzj9V0kH9rcQwqKt0qxDHUBBUDV7tDXK6WVyZ1RSKdeOoo0tLURxC3kHKKvjiH3Bb7xLrctVLQM4FqW8FXu8om1Mp2flDFATVfSnKR8WlwqqWUunnf6Y_sPsWqv5yr-ti9eizjjaUA4YJwwLdH6HdYaHM7u4g6_xDMU44VReXG0U3_Dv_9omqy987m2n733y_AG5sr2M</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>Ornoy, A</creator><creator>Ratzon, N</creator><creator>Greenbaum, C</creator><creator>Peretz, E</creator><creator>Soriano, D</creator><creator>Dulitzky, M</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope></search><sort><creationdate>19980901</creationdate><title>Neurobehaviour of school age children born to diabetic mothers</title><author>Ornoy, A ; Ratzon, N ; Greenbaum, C ; Peretz, E ; Soriano, D ; Dulitzky, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b610t-3280382c19fa319a64f19c3ccd0e533b96d6a8c032f7356da59d56d9c4b058b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Age</topic><topic>Associated diseases and complications</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Biological and medical sciences</topic><topic>Birth weight</topic><topic>Child</topic><topic>Children & youth</topic><topic>Cognition Disorders - etiology</topic><topic>Congenital diseases</topic><topic>Diabetes</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Education</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hyperactivity</topic><topic>Intelligence Tests</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Motor Skills</topic><topic>Motor Skills Disorders - etiology</topic><topic>neurological functions</topic><topic>Newborn babies</topic><topic>Original</topic><topic>Pregnancy</topic><topic>Pregnancy in Diabetics</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>school age children</topic><topic>Socioeconomics</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ornoy, A</creatorcontrib><creatorcontrib>Ratzon, N</creatorcontrib><creatorcontrib>Greenbaum, C</creatorcontrib><creatorcontrib>Peretz, E</creatorcontrib><creatorcontrib>Soriano, D</creatorcontrib><creatorcontrib>Dulitzky, M</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ornoy, A</au><au>Ratzon, N</au><au>Greenbaum, C</au><au>Peretz, E</au><au>Soriano, D</au><au>Dulitzky, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurobehaviour of school age children born to diabetic mothers</atitle><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><date>1998-09-01</date><risdate>1998</risdate><volume>79</volume><issue>2</issue><spage>F94</spage><epage>F99</epage><pages>F94-F99</pages><issn>1359-2998</issn><eissn>1468-2052</eissn><abstract>AIM To study the neurobehavioural effects that diabetes during pregnancy might have on children by school age. METHODS The neurobehavioural function of 57 school age children born to 48, well controlled diabetic mothers was compared with 57 control children matched for age, birth order, and parental socioeconomic status, using several cognitive, behavioural, sensory and motor neurological tests. RESULTS The IQ scores of the index group children were similar to those of control children (117.7±13.4 vs118.5±10.1). There were no differences between the groups in various sensory motor functions. However, the index group children performed less well than the controls on indices of fine and gross motor functions, as observed on the Bruininks–Oseretzky test of motor proficiency. The scores of children born to diabetic mothers were higher than controls on the Touwen and Prechtl neurological examination. They also performed worse in the Pollack tapper test which is designed to detect minor neurological deficits, inattention, and hyperactivity. The index children had higher scores on the Conners abbreviated parent–teacher questionnaire which measures hyperactivity and inattention. There was a negative correlation between the performance of the index group children on various neurodevelopmental and behavioural tests and the severity of hyperglycaemia, as assessed by blood glycosylated haemoglobin and acetonuria. CONCLUSIONS Diabetes during pregnancy adversely affects some fine neurological functions in children at school age, but not their cognitive scores. These effects are not correlated with the degree of glycaemic control.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>9828733</pmid><doi>10.1136/fn.79.2.F94</doi><oa>free_for_read</oa></addata></record> |
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subjects | Age Associated diseases and complications Attention deficit hyperactivity disorder Biological and medical sciences Birth weight Child Children & youth Cognition Disorders - etiology Congenital diseases Diabetes Diabetes. Impaired glucose tolerance Education Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Follow-Up Studies Hospitals Humans Hyperactivity Intelligence Tests Male Medical sciences Metabolism Motor Skills Motor Skills Disorders - etiology neurological functions Newborn babies Original Pregnancy Pregnancy in Diabetics Prenatal Exposure Delayed Effects school age children Socioeconomics Womens health |
title | Neurobehaviour of school age children born to diabetic mothers |
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