Low cerebral blood flow is a risk factor for severe intraventricular haemorrhage

AIMS To investigate the relation between cerebral blood flow on the first day of postnatal life and the severity of any subsequent germinal matrix haemorrhage–intraventricular haemorrhage (GMH–IVH). METHODS Cerebral blood flow was measured in 24 babies during the first 24 hours of life using near in...

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Bibliographic Details
Published in:Archives of disease in childhood. Fetal and neonatal edition 1999-07, Vol.81 (1), p.F15-F18
Main Authors: Meek, Judith H, Tyszczuk, Lidia, Elwell, Clare E, Wyatt, J S
Format: Article
Language:English
Subjects:
Age
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Babies
Biological and medical sciences
Birth weight
Blood pressure
Brain Ischemia - physiopathology
Carbon dioxide
cerebral blood flow
Cerebral Hemorrhage - etiology
Cerebral Hemorrhage - physiopathology
cerebral ischaemia
Cerebrovascular Circulation - physiology
Cysts
Dopamine
Emergency and intensive care: neonates and children. Prematurity. Sudden death
Flow velocity
Humans
Infant
Infant, Newborn
Infant, Premature
Infants
Infrared spectroscopy
Intensive care medicine
intraventricular haemorrhage
Medical sciences
Molecular weight
near infrared spectroscopy
Original
Respiratory distress syndrome
Risk Factors
Spectroscopy, Near-Infrared
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Summary:AIMS To investigate the relation between cerebral blood flow on the first day of postnatal life and the severity of any subsequent germinal matrix haemorrhage–intraventricular haemorrhage (GMH–IVH). METHODS Cerebral blood flow was measured in 24 babies during the first 24 hours of life using near infrared spectroscopy. Repeated cerebral ultrasound examination was performed to define the maximum extent of GMH–IVH. Infants were classified as: normal scan, minor periventricular haemorrhage (haemorrhage that resolved), or severe GMH–IVH (haemorrhage distending the ventricles, that progressed to either post haemorrhagic dilatation or porencephalic cyst formation). RESULTS Cerebral blood flow was significantly lower in the infants with GMH–IVH (median 7.0 ml/100 g/min) than those without haemorrhage (median 12.2 ml/100 g/min), despite no difference in carbon dioxide tension and a higher mean arterial blood pressure. On subgroup analysis, those infants with severe GMH–IVH had the lowest cerebral blood flow. CONCLUSION A low cerebral blood flow on the first day of life is associated with the subsequent development of severe intraventricular haemorrhage.
ISSN:1359-2998
1468-2052
DOI:10.1136/fn.81.1.F15