Markers of collagen metabolism and insulin-like growth factor binding protein-1 in term infants

AIM To study the relation between fetal growth and markers of collagen metabolism and insulin-like growth factor binding protein-1 (IGFBP-1) in term infants. METHODS Cord vein plasma was obtained from 67 term infants of gestational age 37.1–41.7 weeks (39 appropriate for gestational age (AGA), 11 la...

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Bibliographic Details
Published in:Archives of disease in childhood. Fetal and neonatal edition 2000-07, Vol.83 (1), p.F17-F20
Main Authors: Hytinantti, T, Rutanen, E-M, Turpeinen, M, Sorva, R, Andersson, S
Format: Article
Language:English
Subjects:
Age
Babies
Biological and medical sciences
Biomarkers - blood
Birth weight
Birth Weight - physiology
Body mass index
Collagen
Collagen - blood
Collagen Type I
Embryonic and Fetal Development - physiology
Female
fetus
Fetuses
Gestational Age
growth status
Gynecology. Andrology. Obstetrics
Humans
Infant, Newborn - blood
Infant, Small for Gestational Age - blood
Infants
Insulin
Insulin-Like Growth Factor Binding Protein 1 - blood
insulin-like growth factor binding protein-1
Insulin-like growth factors
Male
Management. Prenatal diagnosis
Medical sciences
Metabolism
Original
Peptide Fragments - blood
Peptides - blood
Pregnancy. Fetus. Placenta
Prenatal development
Procollagen - blood
Studies
Variance analysis
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Summary:AIM To study the relation between fetal growth and markers of collagen metabolism and insulin-like growth factor binding protein-1 (IGFBP-1) in term infants. METHODS Cord vein plasma was obtained from 67 term infants of gestational age 37.1–41.7 weeks (39 appropriate for gestational age (AGA), 11 large for gestational age (LGA; relative birth weight ⩾ 2.0 SD), and 17 small for gestational age (SGA; relative birth weight ⩽ −2.0 SD)) for analysis of markers of metabolism of collagen type I (PICP and ICTP) and III (PIIINP) and of IGFBP-1. RESULTS Negative correlations existed between gestational age and PICP (r = −0.294, p = 0.0158), ICTP (r = −0.338, p = 0.0052), and PIIINP (r = −0.432, p = 0.0003). These correlations were also found in SGA infants (all p 0.05). CONCLUSIONS In the term fetus, collagen metabolism is primarily dependent on maturity and not on intrauterine growth status, whereas IGFBP-1 reflects intrauterine growth independently of maturity.
ISSN:1359-2998
1468-2052
DOI:10.1136/fn.83.1.F17