Postnatal changes in concentrations of free and bound leptin

• Published in: Archives of disease in childhood. Fetal and neonatal edition 2001-09, Vol.85 (2), p.F123-F126
• Main Authors: Hytinantti, T K, Juntunen, M, Koistinen, H A, Koivisto, V A, Karonen, S-L, Andersson, S
• Format: Article
• Language: English
• Subjects: Adipocytes; Age; Anthropometry; Biological and medical sciences; Birth weight; Body mass index; Care and treatment; Chromatography, High Pressure Liquid; Diabetes; Diabetes in pregnancy; Diabetes, Gestational - blood; Diseases; Diseases of mother, fetus and pregnancy; Female; Fetal Blood - metabolism; gestational diabetes mellitus; Glucose; Glucose metabolism; Gynecology. Andrology. Obstetrics; Hematology; Humans; Infant, Newborn - blood; Infants; Insulin; Investigative techniques, diagnostic techniques (general aspects); Leptin; Leptin - blood; Maternal-Fetal Exchange; Medical sciences; Metabolism; Mothers; Obesity; Original; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Plasma; Pregnancy; Pregnancy. Fetus. Placenta; Rodents; Weight control
• ISSN: 1359-2998; 1468-2052
• DOI: 10.1136/fn.85.2.F123

AIM To evaluate the effect of maternal diabetes on the concentrations of free and bound leptin at birth and during postnatal adaptation. METHODS Total, bound, and free leptin concentrations and the percentage of free leptin were measured in cord plasma and plasma at 3 days of age of 13 term infants of mothers with gestational diabetes mellitus (GDM) and 13 term infants of healthy mothers. Gestational age was 40.2 (1.4) weeks, and birth weight was 3693 (549) g (means (SD)). RESULTS At birth, infants of mothers with GDM had significantly higher concentrations of total, bound, and free leptin and a higher percentage of free leptin (all p