Postnatal changes in concentrations of free and bound leptin

AIM To evaluate the effect of maternal diabetes on the concentrations of free and bound leptin at birth and during postnatal adaptation. METHODS Total, bound, and free leptin concentrations and the percentage of free leptin were measured in cord plasma and plasma at 3 days of age of 13 term infants...

Full description

Saved in:
Bibliographic Details
Published in:Archives of disease in childhood. Fetal and neonatal edition 2001-09, Vol.85 (2), p.F123-F126
Main Authors: Hytinantti, T K, Juntunen, M, Koistinen, H A, Koivisto, V A, Karonen, S-L, Andersson, S
Format: Article
Language:English
Subjects:
Adipocytes
Age
Anthropometry
Biological and medical sciences
Birth weight
Body mass index
Care and treatment
Chromatography, High Pressure Liquid
Diabetes
Diabetes in pregnancy
Diabetes, Gestational - blood
Diseases
Diseases of mother, fetus and pregnancy
Female
Fetal Blood - metabolism
gestational diabetes mellitus
Glucose
Glucose metabolism
Gynecology. Andrology. Obstetrics
Hematology
Humans
Infant, Newborn - blood
Infants
Insulin
Investigative techniques, diagnostic techniques (general aspects)
Leptin
Leptin - blood
Maternal-Fetal Exchange
Medical sciences
Metabolism
Mothers
Obesity
Original
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Plasma
Pregnancy
Pregnancy. Fetus. Placenta
Rodents
Weight control
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-b610t-193b479061f65040ae577ec27379c7600053aa4b5a73f9a76cb19bccc3ab6ed63
cites
container_end_page F126
container_issue 2
container_start_page F123
container_title Archives of disease in childhood. Fetal and neonatal edition
container_volume 85
creator Hytinantti, T K
Juntunen, M
Koistinen, H A
Koivisto, V A
Karonen, S-L
Andersson, S
description AIM To evaluate the effect of maternal diabetes on the concentrations of free and bound leptin at birth and during postnatal adaptation. METHODS Total, bound, and free leptin concentrations and the percentage of free leptin were measured in cord plasma and plasma at 3 days of age of 13 term infants of mothers with gestational diabetes mellitus (GDM) and 13 term infants of healthy mothers. Gestational age was 40.2 (1.4) weeks, and birth weight was 3693 (549) g (means (SD)). RESULTS At birth, infants of mothers with GDM had significantly higher concentrations of total, bound, and free leptin and a higher percentage of free leptin (all p 
doi_str_mv 10.1136/fn.85.2.F123
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1721307</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A78839836</galeid><sourcerecordid>A78839836</sourcerecordid><originalsourceid>FETCH-LOGICAL-b610t-193b479061f65040ae577ec27379c7600053aa4b5a73f9a76cb19bccc3ab6ed63</originalsourceid><addsrcrecordid>eNp9kt2L1DAUxYMo7jr65rMURX2xY27SfBREWAZ3_Rh0wVV8C2kmmc3YJmPTiv73Zpiyo7JKIAm5Pw7n3FyE7gOeA1D-3IW5ZHMyPwVCb6BjqLgsCWbkZr5TVpekruURupPSBmMMQojb6AiAgSBYHKMX5zENQQ-6LcylDmubCh8KE4OxYej14GNIRXSF660tdFgVTRzz3trt4MNddMvpNtl70zlDn05fXSxel8sPZ28WJ8uy4YCHEmraVKLGHBxnuMLaMiGsIYKK2giebTGqddUwLairteCmgboxxlDdcLvidIZe7nW3Y9PZ1d5aq7a973T_U0Xt1Z-V4C_VOn5XOSRQLLLAk0mgj99GmwbV-WRs2-pg45iUAAApgWbw4V_gJo59yOEUoazimDLI0KN_QSAkFqImGZyhZ3tqrVurfHAxWzNrG2x2GIN1Pj-fCClpLekuY3kNntfKdt5cx0_ypo8p9dZdtQOw2g2GckFJpojaDUbGH_zewgM8TUIGHk-ATka3rtfB-HTgKoBKVNXBp0-D_XFV1_1XxfOHMvX-80KdXXx8--7L4lwtM_90zzfd5v8WfwE4DNpk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1780779260</pqid></control><display><type>article</type><title>Postnatal changes in concentrations of free and bound leptin</title><source>PubMed Central</source><creator>Hytinantti, T K ; Juntunen, M ; Koistinen, H A ; Koivisto, V A ; Karonen, S-L ; Andersson, S</creator><creatorcontrib>Hytinantti, T K ; Juntunen, M ; Koistinen, H A ; Koivisto, V A ; Karonen, S-L ; Andersson, S</creatorcontrib><description>AIM To evaluate the effect of maternal diabetes on the concentrations of free and bound leptin at birth and during postnatal adaptation. METHODS Total, bound, and free leptin concentrations and the percentage of free leptin were measured in cord plasma and plasma at 3 days of age of 13 term infants of mothers with gestational diabetes mellitus (GDM) and 13 term infants of healthy mothers. Gestational age was 40.2 (1.4) weeks, and birth weight was 3693 (549) g (means (SD)). RESULTS At birth, infants of mothers with GDM had significantly higher concentrations of total, bound, and free leptin and a higher percentage of free leptin (all p &lt; 0.05). In all infants, these concentrations were significantly lower at 3 days of age than at birth (all p &lt; 0.003), and the differences in concentrations of total, bound, and free leptin between the two groups were no longer significant. In infants of mothers with GDM, the percentage of free leptin remained unchanged, and was higher (p&lt;0.05) than in infants of healthy mothers; in the latter group the percentage of free leptin significantly declined (p = 0.02). CONCLUSIONS GDM appears to influence fetoplacental leptin metabolism. This effect may be mediated through altered maternal glucose metabolism, or insulinaemia, or both.</description><identifier>ISSN: 1359-2998</identifier><identifier>EISSN: 1468-2052</identifier><identifier>DOI: 10.1136/fn.85.2.F123</identifier><identifier>PMID: 11517207</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Adipocytes ; Age ; Anthropometry ; Biological and medical sciences ; Birth weight ; Body mass index ; Care and treatment ; Chromatography, High Pressure Liquid ; Diabetes ; Diabetes in pregnancy ; Diabetes, Gestational - blood ; Diseases ; Diseases of mother, fetus and pregnancy ; Female ; Fetal Blood - metabolism ; gestational diabetes mellitus ; Glucose ; Glucose metabolism ; Gynecology. Andrology. Obstetrics ; Hematology ; Humans ; Infant, Newborn - blood ; Infants ; Insulin ; Investigative techniques, diagnostic techniques (general aspects) ; Leptin ; Leptin - blood ; Maternal-Fetal Exchange ; Medical sciences ; Metabolism ; Mothers ; Obesity ; Original ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Plasma ; Pregnancy ; Pregnancy. Fetus. Placenta ; Rodents ; Weight control</subject><ispartof>Archives of disease in childhood. Fetal and neonatal edition, 2001-09, Vol.85 (2), p.F123-F126</ispartof><rights>Royal College of Paediatrics and Child Health</rights><rights>2002 INIST-CNRS</rights><rights>COPYRIGHT 2001 BMJ Publishing Group Ltd.</rights><rights>Copyright: 2001 Royal College of Paediatrics and Child Health</rights><rights>Copyright National Library of Medicine - MEDLINE Abstracts Sep 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b610t-193b479061f65040ae577ec27379c7600053aa4b5a73f9a76cb19bccc3ab6ed63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721307/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721307/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=14114744$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11517207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hytinantti, T K</creatorcontrib><creatorcontrib>Juntunen, M</creatorcontrib><creatorcontrib>Koistinen, H A</creatorcontrib><creatorcontrib>Koivisto, V A</creatorcontrib><creatorcontrib>Karonen, S-L</creatorcontrib><creatorcontrib>Andersson, S</creatorcontrib><title>Postnatal changes in concentrations of free and bound leptin</title><title>Archives of disease in childhood. Fetal and neonatal edition</title><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><description>AIM To evaluate the effect of maternal diabetes on the concentrations of free and bound leptin at birth and during postnatal adaptation. METHODS Total, bound, and free leptin concentrations and the percentage of free leptin were measured in cord plasma and plasma at 3 days of age of 13 term infants of mothers with gestational diabetes mellitus (GDM) and 13 term infants of healthy mothers. Gestational age was 40.2 (1.4) weeks, and birth weight was 3693 (549) g (means (SD)). RESULTS At birth, infants of mothers with GDM had significantly higher concentrations of total, bound, and free leptin and a higher percentage of free leptin (all p &lt; 0.05). In all infants, these concentrations were significantly lower at 3 days of age than at birth (all p &lt; 0.003), and the differences in concentrations of total, bound, and free leptin between the two groups were no longer significant. In infants of mothers with GDM, the percentage of free leptin remained unchanged, and was higher (p&lt;0.05) than in infants of healthy mothers; in the latter group the percentage of free leptin significantly declined (p = 0.02). CONCLUSIONS GDM appears to influence fetoplacental leptin metabolism. This effect may be mediated through altered maternal glucose metabolism, or insulinaemia, or both.</description><subject>Adipocytes</subject><subject>Age</subject><subject>Anthropometry</subject><subject>Biological and medical sciences</subject><subject>Birth weight</subject><subject>Body mass index</subject><subject>Care and treatment</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Diabetes</subject><subject>Diabetes in pregnancy</subject><subject>Diabetes, Gestational - blood</subject><subject>Diseases</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>gestational diabetes mellitus</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hematology</subject><subject>Humans</subject><subject>Infant, Newborn - blood</subject><subject>Infants</subject><subject>Insulin</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Maternal-Fetal Exchange</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Mothers</subject><subject>Obesity</subject><subject>Original</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Plasma</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Rodents</subject><subject>Weight control</subject><issn>1359-2998</issn><issn>1468-2052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNp9kt2L1DAUxYMo7jr65rMURX2xY27SfBREWAZ3_Rh0wVV8C2kmmc3YJmPTiv73Zpiyo7JKIAm5Pw7n3FyE7gOeA1D-3IW5ZHMyPwVCb6BjqLgsCWbkZr5TVpekruURupPSBmMMQojb6AiAgSBYHKMX5zENQQ-6LcylDmubCh8KE4OxYej14GNIRXSF660tdFgVTRzz3trt4MNddMvpNtl70zlDn05fXSxel8sPZ28WJ8uy4YCHEmraVKLGHBxnuMLaMiGsIYKK2giebTGqddUwLairteCmgboxxlDdcLvidIZe7nW3Y9PZ1d5aq7a973T_U0Xt1Z-V4C_VOn5XOSRQLLLAk0mgj99GmwbV-WRs2-pg45iUAAApgWbw4V_gJo59yOEUoazimDLI0KN_QSAkFqImGZyhZ3tqrVurfHAxWzNrG2x2GIN1Pj-fCClpLekuY3kNntfKdt5cx0_ypo8p9dZdtQOw2g2GckFJpojaDUbGH_zewgM8TUIGHk-ATka3rtfB-HTgKoBKVNXBp0-D_XFV1_1XxfOHMvX-80KdXXx8--7L4lwtM_90zzfd5v8WfwE4DNpk</recordid><startdate>20010901</startdate><enddate>20010901</enddate><creator>Hytinantti, T K</creator><creator>Juntunen, M</creator><creator>Koistinen, H A</creator><creator>Koivisto, V A</creator><creator>Karonen, S-L</creator><creator>Andersson, S</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ</general><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><general>National Library of Medicine - MEDLINE Abstracts</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20010901</creationdate><title>Postnatal changes in concentrations of free and bound leptin</title><author>Hytinantti, T K ; Juntunen, M ; Koistinen, H A ; Koivisto, V A ; Karonen, S-L ; Andersson, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b610t-193b479061f65040ae577ec27379c7600053aa4b5a73f9a76cb19bccc3ab6ed63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adipocytes</topic><topic>Age</topic><topic>Anthropometry</topic><topic>Biological and medical sciences</topic><topic>Birth weight</topic><topic>Body mass index</topic><topic>Care and treatment</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Diabetes</topic><topic>Diabetes in pregnancy</topic><topic>Diabetes, Gestational - blood</topic><topic>Diseases</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>gestational diabetes mellitus</topic><topic>Glucose</topic><topic>Glucose metabolism</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hematology</topic><topic>Humans</topic><topic>Infant, Newborn - blood</topic><topic>Infants</topic><topic>Insulin</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Maternal-Fetal Exchange</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Mothers</topic><topic>Obesity</topic><topic>Original</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Plasma</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Rodents</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hytinantti, T K</creatorcontrib><creatorcontrib>Juntunen, M</creatorcontrib><creatorcontrib>Koistinen, H A</creatorcontrib><creatorcontrib>Koivisto, V A</creatorcontrib><creatorcontrib>Karonen, S-L</creatorcontrib><creatorcontrib>Andersson, S</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hytinantti, T K</au><au>Juntunen, M</au><au>Koistinen, H A</au><au>Koivisto, V A</au><au>Karonen, S-L</au><au>Andersson, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postnatal changes in concentrations of free and bound leptin</atitle><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><date>2001-09-01</date><risdate>2001</risdate><volume>85</volume><issue>2</issue><spage>F123</spage><epage>F126</epage><pages>F123-F126</pages><issn>1359-2998</issn><eissn>1468-2052</eissn><abstract>AIM To evaluate the effect of maternal diabetes on the concentrations of free and bound leptin at birth and during postnatal adaptation. METHODS Total, bound, and free leptin concentrations and the percentage of free leptin were measured in cord plasma and plasma at 3 days of age of 13 term infants of mothers with gestational diabetes mellitus (GDM) and 13 term infants of healthy mothers. Gestational age was 40.2 (1.4) weeks, and birth weight was 3693 (549) g (means (SD)). RESULTS At birth, infants of mothers with GDM had significantly higher concentrations of total, bound, and free leptin and a higher percentage of free leptin (all p &lt; 0.05). In all infants, these concentrations were significantly lower at 3 days of age than at birth (all p &lt; 0.003), and the differences in concentrations of total, bound, and free leptin between the two groups were no longer significant. In infants of mothers with GDM, the percentage of free leptin remained unchanged, and was higher (p&lt;0.05) than in infants of healthy mothers; in the latter group the percentage of free leptin significantly declined (p = 0.02). CONCLUSIONS GDM appears to influence fetoplacental leptin metabolism. This effect may be mediated through altered maternal glucose metabolism, or insulinaemia, or both.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>11517207</pmid><doi>10.1136/fn.85.2.F123</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1359-2998
ispartof Archives of disease in childhood. Fetal and neonatal edition, 2001-09, Vol.85 (2), p.F123-F126
issn 1359-2998
1468-2052
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1721307
source PubMed Central
subjects Adipocytes
Age
Anthropometry
Biological and medical sciences
Birth weight
Body mass index
Care and treatment
Chromatography, High Pressure Liquid
Diabetes
Diabetes in pregnancy
Diabetes, Gestational - blood
Diseases
Diseases of mother, fetus and pregnancy
Female
Fetal Blood - metabolism
gestational diabetes mellitus
Glucose
Glucose metabolism
Gynecology. Andrology. Obstetrics
Hematology
Humans
Infant, Newborn - blood
Infants
Insulin
Investigative techniques, diagnostic techniques (general aspects)
Leptin
Leptin - blood
Maternal-Fetal Exchange
Medical sciences
Metabolism
Mothers
Obesity
Original
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Plasma
Pregnancy
Pregnancy. Fetus. Placenta
Rodents
Weight control
title Postnatal changes in concentrations of free and bound leptin
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T11%3A12%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Postnatal%20changes%20in%20concentrations%20of%20free%20and%20bound%20leptin&rft.jtitle=Archives%20of%20disease%20in%20childhood.%20Fetal%20and%20neonatal%20edition&rft.au=Hytinantti,%20T%20K&rft.date=2001-09-01&rft.volume=85&rft.issue=2&rft.spage=F123&rft.epage=F126&rft.pages=F123-F126&rft.issn=1359-2998&rft.eissn=1468-2052&rft_id=info:doi/10.1136/fn.85.2.F123&rft_dat=%3Cgale_pubme%3EA78839836%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-b610t-193b479061f65040ae577ec27379c7600053aa4b5a73f9a76cb19bccc3ab6ed63%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1780779260&rft_id=info:pmid/11517207&rft_galeid=A78839836&rfr_iscdi=true