Nasal potential difference increases with gestation in moderately preterm neonates on the first postnatal day

At birth the mammalian airway switches from liquid secretion to absorption, an important mechanism in lung liquid clearance. Airway ion transport was examined on the first postnatal day in 38 moderately preterm infants (29–36 weeks gestation). The absorptive airway ion transport capacity was well de...

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Bibliographic Details
Published in:Archives of disease in childhood. Fetal and neonatal edition 2005-03, Vol.90 (2), p.F172-F173
Main Authors: Gaillard, E A, Shaw, N J, Wallace, H L, Subhedar, N V, Southern, K W
Format: Article
Language:English
Subjects:
Absorption
airway epithelium
Biological Transport
Birth weight
chloride transport
ENaC
epithelial sodium channel
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Ion transport
Male
Membrane Potentials - physiology
Neonates
potential difference
Premature birth
Regression Analysis
Respiration, Artificial
respiratory distress
Respiratory Distress Syndrome, Newborn - metabolism
Rodents
Short Report
Sodium
Sodium - metabolism
Sodium - pharmacokinetics
Sodium Channels - metabolism
sodium transport
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Summary:At birth the mammalian airway switches from liquid secretion to absorption, an important mechanism in lung liquid clearance. Airway ion transport was examined on the first postnatal day in 38 moderately preterm infants (29–36 weeks gestation). The absorptive airway ion transport capacity was well developed regardless of respiratory condition and there was little capacity for Cl− secretion.
ISSN:1359-2998
1468-2052
DOI:10.1136/adc.2004.054494