Genetic heterogeneity in familial exudative vitreoretinopathy; exclusion of the EVR1 locus on chromosome 11q in a large autosomal dominant pedigree

BACKGROUND/AIMS Familial exudative vitreoretinopathy (FEVR) is associated with mutations in the Norrie disease gene in X linked pedigrees and with linkage to the EVR1 locus at 11q13 in autosomal dominant cases. A large autosomal dominant FEVR family was studied, both clinically and by linkage analys...

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Bibliographic Details
Published in:British journal of ophthalmology 2000-04, Vol.84 (4), p.358-363
Main Authors: Bamashmus, M A, Downey, L M, Inglehearn, C F, Gupta, S R, Mansfield, D C
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Child
Chromosomes, Human, Pair 11
Exudates and Transudates
familial exudative vitreoretinopathy
Female
Fundus Oculi
Genes, Dominant
Genetic Heterogeneity
Genetic Linkage
Humans
Lod Score
Male
Medical sciences
Middle Aged
Ophthalmology
Original articles - Clinical science
Pedigree
retinal degeneration
Retinal Diseases - genetics
Retinopathies
vitreoretinopathy
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Summary:BACKGROUND/AIMS Familial exudative vitreoretinopathy (FEVR) is associated with mutations in the Norrie disease gene in X linked pedigrees and with linkage to the EVR1 locus at 11q13 in autosomal dominant cases. A large autosomal dominant FEVR family was studied, both clinically and by linkage analysis, to determine whether it differed from the known forms of FEVR. METHODS Affected members and obligate gene carriers from this family were examined by slit lamp biomicroscopy, indirect ophthalmoscopy, and in some cases fluorescein angiography. Patient DNAs were genotyped for markers at the EVR1 locus on chromosome 11q13. RESULTS The clinical evaluation in this family is consistent with previous descriptions of FEVR pedigrees, but linkage analysis proves that it has a form of FEVR genetically distinct from the EVR1 locus on 11q. CONCLUSION This proves that there are at least three different loci associated with comparable FEVR phenotypes, a situation similar to that existing for many forms of retinal degeneration.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.84.4.358