A comparison of latanoprost and dorzolamide in patients with glaucoma and ocular hypertension: a 3 month, randomised study

AIMS To compare the effects on intraocular pressure (IOP) and side effects of monotherapy with either latanoprost or dorzolamide in patients with glaucoma or ocular hypertension. METHODS 224 patients with open angle glaucoma or ocular hypertension were recruited to a 3 month open labelled study. Pre...

Full description

Saved in:
Bibliographic Details
Published in:British journal of ophthalmology 2000-06, Vol.84 (6), p.579-582
Main Author: O'Donoghue, E P
Format: Article
Language:English
Subjects:
Clinical trials
dorzolamide
Drug dosages
Glaucoma
Hypertension
intraocular pressure
latanoprost
monotherapy
ocular hypertension
Original articles - Clinical science
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:AIMS To compare the effects on intraocular pressure (IOP) and side effects of monotherapy with either latanoprost or dorzolamide in patients with glaucoma or ocular hypertension. METHODS 224 patients with open angle glaucoma or ocular hypertension were recruited to a 3 month open labelled study. Previous glaucoma medications were washed out and the patients were randomised to receive either latanoprost 0.005% once daily or dorzolamide 2% three times daily. RESULTS Of 224 patients 213 were included in the analysis of efficacy. After 3 months, latanoprost reduced mean baseline diurnal IOP from 27.2 (SD 3.0) mm Hg by 8.5 (3.3) mm Hg. The corresponding figures for dorzolamide were 27.2 (3.4) and 5.6 (2.6) mm Hg. The difference of 2.9 mm Hg (95% CI: 2.3–3.6) was highly significant (p
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.84.6.579