Screening for CMV retinitis using chromatic discrimination thresholds and achromatic contrast sensitivity

BACKGROUND Many patients with cytomegalovirus retinitis (CMVR) are unaware of visual disturbance so screening is advocated for patients with HIV and low CD4 counts. Many tests of retinal function have been recommended but few are effective at detecting CMVR. We assess the potential of chromatic disc...

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Bibliographic Details
Published in:British journal of ophthalmology 2000-08, Vol.84 (8), p.877-880
Main Authors: Newsom, Richard S B, Ong, Gek L, Jackson, Tim L, Coldrick, Ian, Ripley, Lionel G, Fisher, Martin, Casswell, Anthony G
Format: Article
Language:English
Subjects:
achromatic contrast sensitivity
Acquired immune deficiency syndrome
Adult
AIDS
AIDS-Related Opportunistic Infections - complications
AIDS/HIV
Biological and medical sciences
Case-Control Studies
chromatic discrimination threshold
Color Perception - physiology
Color Vision Defects - complications
Color Vision Defects - diagnosis
Contrast Sensitivity - physiology
Cytomegalovirus
Cytomegalovirus Retinitis - complications
Cytomegalovirus Retinitis - diagnosis
Discrimination
HIV
HIV Infections - complications
HIV retinopathy
Human immunodeficiency virus
Human viral diseases
Humans
Infections
Infectious diseases
Mass Screening - methods
Medical sciences
Methods
microangiopathy
Original articles - Clinical science
Patients
Polymerase chain reaction
retinitis
screening
Studies
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
Visual Acuity - physiology
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Summary:BACKGROUND Many patients with cytomegalovirus retinitis (CMVR) are unaware of visual disturbance so screening is advocated for patients with HIV and low CD4 counts. Many tests of retinal function have been recommended but few are effective at detecting CMVR. We assess the potential of chromatic discrimination thresholds and achromatic contrast sensitivity as screening tests for patients with CMVR. METHOD 11 HIV+ patients with CMVR, 16 age matched HIV+ patients, and 29 age matched controls were recruited. Visual acuity, chromatic discrimination thresholds, and achromatic contrast sensitivity were measured. Fundal examination was performed by slit lamp biomicroscopy for HIV+ patients. Those with CMVR were photographed and the CMVR graded from the photographs. RESULTS Loss of chromatic discrimination was found in patients with CMVR (tritan p
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.84.8.877