Assessment of early retinal changes in diabetes using a new multifocal ERG protocol

• Published in: British journal of ophthalmology 2001-04, Vol.85 (4), p.414-419
• Main Authors: Shimada, Yoshiaki, Li, Yong, Bearse, Marcus A, Sutter, Erich E, Fung, Wayne
• Format: Article
• Language: English
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Associated diseases and complications; Biological and medical sciences; Case-Control Studies; Contact lenses; Diabetes; Diabetes. Impaired glucose tolerance; Diabetic retinopathy; Diabetic Retinopathy - physiopathology; Electrodes; Electroretinography; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Humans; Male; Medical sciences; Middle Aged; multifocal electroretinogram; Noise; Original articles - Clinical science; Physiological aspects; Predictive Value of Tests; Reproducibility of Results; Retinal degeneration; Studies
• ISSN: 0007-1161; 1468-2079
• DOI: 10.1136/bjo.85.4.414

AIMS To assess early functional retinal changes in diabetics without retinopathy, a new multifocal stimulus paradigm was used that emphasises fast adaptive response contributions. METHODS 25 normal control subjects (25 eyes) and 11 diabetics without retinopathy (22 eyes) served as subjects. Stimulation and analysis were performed with Veris Science 4.0. A stimulation protocol was used that combines regular multifocal flicker stimulation with a periodic “global” flash inserted between the multifocal stimuli. The multifocal stimuli were presented four video frames apart. The global flash covered the entire screen in the third frame of the four frame interval. The remaining two frames were dark. The periodic global flashes could only contribute to the focal responses if they were affected by the multifocal stimulation. A non-linear component induced by the interaction of the focal and global flashes was observed. The differences between control subjects and diabetics were assessed in both the multifocal responses and their induced effect on the following global flashes. RESULTS The responses to focal flashes were reduced significantly in diabetics matched in age to the control subjects. The induced components showed large intersubject variability in controls and patients, and did not differ significantly between the two groups. CONCLUSION The periodic global flashes produce a greater multifocal response reduction in diabetics than in normals, indicating impairment in the rate or magnitude of recovery from the bright preceding stimulus. The new stimulation protocol reveals early changes in retinal function of diabetics.