Human papillomavirus in pterygium

AIM To determine the prevalence and significance of human papillomaviral types in conjunctival pterygia. METHODS Polymerase chain reaction technology was used to identify the presence of human papillomavirus (HPV) in 10 formalin fixed paraffin embedded pterygia samples. 10 conjunctival papillomas we...

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Bibliographic Details
Published in:British journal of ophthalmology 2001-07, Vol.85 (7), p.782-784
Main Authors: Gallagher, M J, Giannoudis, A, Herrington, C S, Hiscott, P
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cervical cancer
Cornea - virology
Diseases of eyelid, conjunctiva and lacrimal tracts
DNA, Viral - analysis
Female
Formaldehyde
Human papillomavirus
Humans
Male
Medical sciences
Middle Aged
Ophthalmology
Papilloma
Papillomaviridae - genetics
Papillomaviridae - isolation & purification
Papillomavirus Infections - complications
Papillomaviruses
Paraffin wax
Pathology
Physiological aspects
Polymerase chain reaction
Polymerase Chain Reaction - methods
pterygium
Pterygium - virology
Recurrence
Scientific Correspondence
Skin cancer
Tumor Virus Infections - complications
Viral infections
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Summary:AIM To determine the prevalence and significance of human papillomaviral types in conjunctival pterygia. METHODS Polymerase chain reaction technology was used to identify the presence of human papillomavirus (HPV) in 10 formalin fixed paraffin embedded pterygia samples. 10 conjunctival papillomas were used as positive controls. 20 conjunctival samples, 10 with primary acquired melanosis and 10 with malignant melanoma, were used as negative controls. Sample subgroups were of equal sex, race, and age distribution to eliminate bias. All samples were further analysed (for 21 HPV types) using dot-blot hybridisation techniques. RESULTS HPV was identified in 90% of the conjunctival papillomas, 50% of the pterygia samples, but no HPV was detected in the negative control group. Two pterygia showed type 6, two type 11, and one type 16. These three HPV types were also detected in papillomas. CONCLUSION These results suggest that HPV may be involved in the pathogenesis of pterygia and that broadly the same HPV types are found in pterygia and in papillomas. Persistent conjunctival HPV may possibly play a part in the recurrence of pterygia post excision but further larger studies are required to elucidate this hypothesis.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.85.7.782