Human papillomavirus in conjunctival papilloma

AIM To examine conjunctival papillomas for the presence of human papillomavirus (HPV) and koilocytosis. METHODS Archival paraffin embedded tissue from 55 conjunctival papillomas was analysed for the presence of HPV by polymerase chain reaction and subsequent filter hybridisation. Histological sectio...

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Bibliographic Details
Published in:British journal of ophthalmology 2001-07, Vol.85 (7), p.785-787
Main Authors: Sjö, Nicolai Christian, Heegaard, Steffen, Prause, Jan Ulrik, von Buchwald, Christian, Lindeberg, Henning
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cervical cancer
conjunctiva
Conjunctiva - pathology
Conjunctival Neoplasms - pathology
Conjunctival Neoplasms - virology
Deoxyribonucleic acid
Diseases of eyelid, conjunctiva and lacrimal tracts
DNA
DNA, Viral - analysis
Female
Genetic testing
Human papillomavirus
Humans
Infections
koilocytosis
Male
Medical sciences
Middle Aged
Ophthalmology
Papilloma
Papilloma - pathology
Papilloma - virology
Papillomaviridae - genetics
Papillomaviridae - isolation & purification
Papillomaviruses
Paraffin wax
Physiological aspects
Polymerase chain reaction
Polymerase Chain Reaction - methods
Retrospective Studies
Scientific Correspondence
Studies
Tumors
Vaccines
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Summary:AIM To examine conjunctival papillomas for the presence of human papillomavirus (HPV) and koilocytosis. METHODS Archival paraffin embedded tissue from 55 conjunctival papillomas was analysed for the presence of HPV by polymerase chain reaction and subsequent filter hybridisation. Histological sections of the 55 papillomas were evaluated for the presence of koilocytosis. RESULTS HPV was present in 48 of 52 (92%) β globin positive papillomas. HPV type 6/11 were found in 40 of 47 investigated papillomas and a double infection with HPV 6/11 and 16 was identified in a single papilloma. In six papillomas the HPV type could not be identified. Koilocytosis was present in 22 of 55 papillomas (40%). CONCLUSION There is a strong association between HPV and conjunctival papillomas. HPV type 6/11 is the most common HPV type in conjunctival papilloma. The sensitivity of koilocytosis as an indicator of HPV in conjunctival papilloma is low.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.85.7.785