Effects of 12 months of exercise training on salivary secretory IgA levels in elderly subjects

Background: The immune system declines in efficiency with advancing age, making the elderly less resistant to pathogenic microorganisms. Upper respiratory tract infection (URTI) is a common illness. Recent studies have shown that suppression of secretory immunoglobulin A (SIgA) is associated with in...

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Bibliographic Details
Published in:British journal of sports medicine 2003-02, Vol.37 (1), p.76-79
Main Authors: Akimoto, T, Kumai, Y, Akama, T, Hayashi, E, Murakami, H, Soma, R, Kuno, S, Kono, I
Format: Article
Language:English
Subjects:
Age
Aged
Effects
elderly
Enzyme-Linked Immunosorbent Assay - methods
Exercise
Exercise - physiology
Female
heart rate
Humans
IgA
Immune system
Immunoglobulin A, Secretory - analysis
Immunoglobulins
infection
Infections
Lymphocytes
Male
maximal oxygen uptake
Microorganisms
Middle Aged
natural killer
Older people
Original
Oxygen Consumption
Physical fitness
Respiratory system
saliva
Saliva - immunology
Saliva - metabolism
secretory immunoglobulin A
Secretory Rate
SIgA
Sports medicine
Studies
Training
upper respiratory tract infection
URTI
Vo2max
Young adults
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Summary:Background: The immune system declines in efficiency with advancing age, making the elderly less resistant to pathogenic microorganisms. Upper respiratory tract infection (URTI) is a common illness. Recent studies have shown that suppression of secretory immunoglobulin A (SIgA) is associated with increased incidence of URTI. Objective: To assess the effect of exercise on salivary SIgA in elderly subjects. Methods: Forty five elderly subjects (18 men, 27 women; mean (SD) age 64.9 (8.4) years) performed both 60 minute resistance and 60 minute moderate endurance training a week for 12 months. Saliva samples were obtained before training, and at four and 12 months during the training period. Salivary SIgA concentrations were measured by enzyme linked immunosorbent assay, and the SIgA secretion rate was calculated. Results: SIgA concentrations before training, and at four and 12 months during training were 24.7 (14.4), 27.2 (14.2), and 33.8 (18.5) μg/ml respectively. SIgA secretion rates were 29.5 (26.0), 33.8 (27.2) and 46.5 (35.1) μg/min respectively. The results indicate that both the concentration and secretion rate of SIgA significantly (p
ISSN:0306-3674
1473-0480
DOI:10.1136/bjsm.37.1.76