Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study

Background—Increased concentrations of 5-hydroxytryptamine (5-HT) can be detected in the systemic circulation after a meal and may be involved in the physiological control of gastrointestinal motility. Abnormalities of 5-HT release after a meal might explain some of the postprandial symptoms associa...

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Bibliographic Details
Published in:Gut 1998-01, Vol.42 (1), p.42-46
Main Authors: Bearcroft, C P, Perrett, D, Farthing, M J G
Format: Article
Language:English
Subjects:
5-hydroxytryptamine
Adolescent
Adult
Area Under Curve
Biological and medical sciences
Blood platelets
Chromatography, High Pressure Liquid
Colonic Diseases, Functional - blood
Colonic Diseases, Functional - urine
Creatinine - urine
Diarrhea - blood
diarrhoea predominant irritable bowel syndrome
Eating
Female
Fluorometry
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Hydroxyindoleacetic Acid - urine
Irritable Bowel Syndrome
Male
Medical sciences
Middle Aged
Motility
Other diseases. Semiology
Pilot Projects
Plasma
postprandial
Postprandial Period
Serotonin - blood
Statistics, Nonparametric
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Urine
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Summary:Background—Increased concentrations of 5-hydroxytryptamine (5-HT) can be detected in the systemic circulation after a meal and may be involved in the physiological control of gastrointestinal motility. Abnormalities of 5-HT release after a meal might explain some of the postprandial symptoms associated with the irritable bowel syndrome (IBS). Aim—To investigate the effect of a standard meal on plasma 5-HT and urinary 5-hydroxyindole acetic acid (5-HIAA) concentrations in patients with diarrhoea predominant IBS and in healthy volunteers. Methods—After an overnight fast, six volunteers and five patients with IBS were given a carbohydrate-rich meal. Blood and urine samples were taken before and for four hours after the meal. Platelet-poor plasma 5-HT and urinary 5-HIAA were analysed by reversed phase high performance liquid chromatography with fluorometric detection. 5-HIAA was expressed as a ratio with urinary creatinine concentration, which was measured by spectrophotometry. Results—During the four hour postprandial period, 5-HT concentrations were significantly higher in patients with IBS than in healthy volunteers at 0.5 hours (p
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.42.1.42