Gut epithelium: food processor for the mucosal immune system?

Macromolecular transport by the adult gut epithelium was established in the 1970s, in particular by the extensive work from Allan Walker's laboratory. 1 Some answers (but even more questions!) have been provided in the past decade by workers analysing antigen processing and presentation by isol...

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Bibliographic Details
Published in:Gut 1998-04, Vol.42 (4), p.455-456
Main Author: BLAND, P W
Format: Article
Language:English
Subjects:
Amino acids
Antigens
Antigens - metabolism
Biological Transport
Cytokines
Enzymes
Epithelial Cells - immunology
Epithelial Cells - metabolism
Food
HLA-DR Antigens - immunology
HT29 Cells
Humans
Immune system
Immunity, Mucosal - physiology
Interferon-gamma - immunology
Intestinal Mucosa - immunology
Molecular weight
Peptides
Proteins
Small intestine
Studies
Citations: Items that cite this one
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Summary:Macromolecular transport by the adult gut epithelium was established in the 1970s, in particular by the extensive work from Allan Walker's laboratory. 1 Some answers (but even more questions!) have been provided in the past decade by workers analysing antigen processing and presentation by isolated gut epithelial cells. 2 These studies, which were stimulated by the discovery of MHC antigen expression by absorptive enterocytes, give some indication that antigens are modified by enterocytes, but prolonged analysis of isolated enterocytes in primary culture is impossible.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.42.4.455