Cytokine regulation of epithelial permeability and ion transport

[...]cytokines act in a coordinated interplay of often redundant, pleiotropic and occasionally opposing actions. 6 Secondly, given the complex intercellular signalling that occurs within the gut, 7 cytokine effects may involve other, non-cytokine mediators. 8-10 Finally, virtually every putative med...

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Bibliographic Details
Published in:Gut 1999-02, Vol.44 (2), p.283-289
Main Authors: McKAY, D M, BAIRD, A W
Format: Article
Language:English
Subjects:
Antigen Presentation
Antigens
Biological and medical sciences
Crohn's disease
Cytokines
Cytokines - physiology
Epithelium - immunology
Fundamental and applied biological sciences. Psychology
Genes
Humans
Immunology
Inflammatory bowel disease
Inflammatory Bowel Diseases - immunology
Intestinal Absorption - immunology
Intestinal Mucosa - immunology
Intestine. Mesentery
Ion Transport - immunology
Permeability
Proteins
Review
Signal transduction
Studies
Tumor necrosis factor-TNF
Vertebrates: digestive system
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Summary:[...]cytokines act in a coordinated interplay of often redundant, pleiotropic and occasionally opposing actions. 6 Secondly, given the complex intercellular signalling that occurs within the gut, 7 cytokine effects may involve other, non-cytokine mediators. 8-10 Finally, virtually every putative mediator of inflammation has been implicated in diseases of the intestine, representing at one time the academic pharmacologist's dream and the therapist's nightmare. [...]cell lines are now a basic tool in cell biology, allowing both generation and testing of novel hypotheses which may unveil potential therapeutic targets which require subsequent validation by whole tissue or animal studies in advance of experimental clinical manipulation(s).
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.44.2.283