Gall bladder and bowel: the links multiply

Recently, the state of the gall bladder in patients with constipation has been attracting attention because of growing evidence that cholesterol gallstones can result from slow intestinal transit. 1-3 Slow transit allows the colon to absorb excessive amounts of bacterially degraded substances, inclu...

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Bibliographic Details
Published in:Gut 1999-08, Vol.45 (2), p.166-167
Main Author: HEATON, K W
Format: Article
Language:English
Subjects:
Bile
Bile Acids and Salts - physiology
Bladder
Cholesterol
Constipation
Constipation - etiology
Constipation - physiopathology
Gallbladder Diseases - physiopathology
Gallbladder Emptying - physiology
Humans
Irritable bowel syndrome
Motility
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Summary:Recently, the state of the gall bladder in patients with constipation has been attracting attention because of growing evidence that cholesterol gallstones can result from slow intestinal transit. 1-3 Slow transit allows the colon to absorb excessive amounts of bacterially degraded substances, including the toxic bile acid, deoxycholic acid (DCA). Is it a problem of understimulation? Because the gall bladder's response to sham feeding involves vagal cholinergic stimulation, Penning et al conclude that failure to respond is a sign of vagal neuropathy.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.45.2.166