Heterogeneity in the Helicobacter pylori vacA and cagA genes: association with gastroduodenal disease in South Africa?

BACKGROUND Helicobacter pylori infection is universally associated with gastritis, but only sometimes with clinically significant disease. Candidate virulence markers seem to be useful in identifying the pathogenic infections in some populations. AIMS To investigate the association between putative...

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Bibliographic Details
Published in:Gut 1999-10, Vol.45 (4), p.499-502
Main Authors: Kidd, M, Lastovica, A J, Atherton, J C, Louw, J A
Format: Article
Language:English
Subjects:
adenocarcinoma
Adenocarcinoma - microbiology
Antigens, Bacterial - genetics
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Bacterial Proteins - genetics
Biological and medical sciences
Biopsy
cagA
Deoxyribonucleic acid
DNA
Endoscopy
Gastric cancer
Gastritis - microbiology
Gastrointestinal Diseases - microbiology
Genes
Genotype
Genotype & phenotype
Helicobacter pylori
Helicobacter pylori - classification
Helicobacter pylori - genetics
Helicobacter pylori - pathogenicity
Human bacterial diseases
Humans
Infections
Infectious diseases
Medical sciences
Molecular weight
Pathology
Peptic Ulcer - microbiology
peptic ulceration
Polymerase Chain Reaction
Population
Proteins
South Africa
Species Specificity
Stomach Neoplasms - microbiology
Studies
Tropical medicine
vacuolating cytotoxin
Virulence
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Summary:BACKGROUND Helicobacter pylori infection is universally associated with gastritis, but only sometimes with clinically significant disease. Candidate virulence markers seem to be useful in identifying the pathogenic infections in some populations. AIMS To investigate the association between putative virulence markers and disease in an African population. METHODS Fifty nineH pylori strains isolated from dyspeptic patients (11 with peptic ulceration, eight with gastric adenocarcinoma, and 28 with no pathology other than gastritis) were studied for differences in the genes vacA andcagA. RESULTS Forty seven (80%) of 59 strains had the vacA signal sequence genotype s1 (one s1a, 46 s1b) and 12 (20%) had subtype s2.vacA mid-region analysis revealed that 40 (68%) strains were vacA m1 and 19 (32%) were m2. All 14 strains from patients with peptic ulceration werevacA s1, in contrast to 23 (66%) of 35 strains from patients with gastritis alone (p
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.45.4.499