Ulcerative colitis in Olmsted County, Minnesota, 1940–1993: incidence, prevalence, and survival

BACKGROUND There is significant geographic variation in the reported incidence of ulcerative colitis. AIMS To update the incidence and prevalence of ulcerative colitis in Olmsted County, Minnesota, examine temporal trends, and determine overall survival. PATIENTS All Olmsted County residents diagnos...

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Bibliographic Details
Published in:Gut 2000-03, Vol.46 (3), p.336-343
Main Authors: Loftus, E V, Silverstein, M D, Sandborn, W J, Tremaine, W J, Harmsen, W S, Zinsmeister, A R
Format: Article
Language:English
Subjects:
Adolescent
Adult
African Americans
Age Distribution
Aged
Aged, 80 and over
Biological and medical sciences
Child
Cohort Studies
Colitis, Ulcerative - epidemiology
Colitis, Ulcerative - mortality
Crohn's disease
Endoscopy
Epidemiology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Incidence
Inflammatory bowel disease
Life expectancy
Male
Medical prognosis
Medical records
Medical sciences
Mens health
Middle Aged
Minnesota - epidemiology
Mortality
Other diseases. Semiology
Population
Prevalence
prognosis
Sex Distribution
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Studies
survival
Survival Rate
Trends
ulcerative colitis
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Summary:BACKGROUND There is significant geographic variation in the reported incidence of ulcerative colitis. AIMS To update the incidence and prevalence of ulcerative colitis in Olmsted County, Minnesota, examine temporal trends, and determine overall survival. PATIENTS All Olmsted County residents diagnosed with ulcerative colitis between 1940 and 1993 (incidence cases), and all residents with ulcerative colitis alive on 1 January 1991 (prevalence cases). METHODS Incidence and prevalence rates were adjusted using 1990 US census figures for whites. The effects of age, sex, and calendar year on incidence rates were evaluated using Poisson regression. Survival from diagnosis was compared with that expected for US north-central whites. RESULTS Between 1940 and 1993, 278 incidence cases were identified, for an adjusted incidence rate of 7.6 cases per 100 000 person years (95% confidence interval (CI), 6.7 to 8.5). On 1 January 1991, there were 218 residents with definite or probable ulcerative colitis, for an adjusted prevalence rate of 229 cases per 100 000 (95% CI, 198 to 260). Increased incidence rates were associated with later calendar years (p
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.46.3.336