Alterations of autonomic nervous activity in recurrence of variant angina

OBJECTIVE To investigate whether autonomic nervous activity is involved in the recurrence of spontaneous coronary spasm in variant angina. DESIGN Retrospective analysis. SETTING Cardiology department of a university hospital. PATIENTS 18 patients with variant angina were divided into single attack g...

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Bibliographic Details
Published in:Heart (British Cardiac Society) 1999-07, Vol.82 (1), p.75-81
Main Authors: Takusagawa, M, Komori, S, Umetani, K, Ishihara, T, Sawanobori, T, Kohno, I, Sano, S, Yin, D, Ijiri, H, Tamura, K
Format: Article
Language:English
Subjects:
Aged
Analysis of Variance
Angina pectoris
Angina Pectoris, Variant - physiopathology
Autonomic Nervous System - physiopathology
Biological and medical sciences
Cardiology. Vascular system
Coronary heart disease
Electrocardiography
Electrocardiography, Ambulatory
Female
Heart
Heart attacks
Heart Rate
Humans
Male
Medical sciences
MemCalc method
Middle Aged
Recurrence
recurrence of coronary spasm
Retrospective Studies
Signal Processing, Computer-Assisted
sympathetic activity
variant angina
Veins & arteries
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Summary:OBJECTIVE To investigate whether autonomic nervous activity is involved in the recurrence of spontaneous coronary spasm in variant angina. DESIGN Retrospective analysis. SETTING Cardiology department of a university hospital. PATIENTS 18 patients with variant angina were divided into single attack group (SA; nine patients) and multiple attack group (MA; nine patients) according to the frequency of ischaemic episodes with ST segment elevation during 24 hour Holter monitoring. METHODS Heart rate variability indices were calculated using MemCalc method, which is a combination of the maximum entropy method for spectral analysis and the non-linear least squares method for fitting analysis, at 30 second intervals for 30 second periods, from 40 minutes before the attack to 30 minutes after the attack. High frequency (HF; 0.04–0.15 Hz) was defined as a marker of parasympathetic activity, and the ratio of low frequency (LF; 0.15–0.40 Hz) to high frequency (LF/HF) as an indicator of sympathetic activity. The averaged value during the 40 to 30 minute period before an attack was defined as the baseline. RESULTS Compared with baseline, the HF component decreased in both groups at two minutes before the attack (p 
ISSN:1355-6037
1468-201X
DOI:10.1136/hrt.82.1.75