Gene therapy made difficult

Stable transgene expression has been demonstrated in immunocompetent mice 10 months after a single injection of "gutless" adenovirus vector expressing α1-antitrypsin from genomic DNA. 5 Furthermore, "gutless" vectors with space for the insertion of 30 kb of DNA allow the prospec...

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Bibliographic Details
Published in:Heart (British Cardiac Society) 1999-07, Vol.82 (1), p.115-115
Main Authors: KINGSTON, P A, HEAGERTY, A M
Format: Article
Language:English
Subjects:
Adenoviruses
Cytomegalovirus
Deoxyribonucleic acid
DNA
Editorials
Gene expression
Gene therapy
Genetic Therapy - methods
Genetic Vectors - adverse effects
Hemophilia
Humans
Inflammation
Inflammation - etiology
Letters to the Editor
Proteins
Studies
Vectors (Biology)
Citations: Items that cite this one
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Summary:Stable transgene expression has been demonstrated in immunocompetent mice 10 months after a single injection of "gutless" adenovirus vector expressing α1-antitrypsin from genomic DNA. 5 Furthermore, "gutless" vectors with space for the insertion of 30 kb of DNA allow the prospect of efficient transgene expression from genomic DNA and production of vectors containing a variety of transgenes, some of which may be aimed at suppression of the host immune response to the vector. [...]while host inflammatory responses have attracted much attention, their practical sequelae are not clearly defined in vascular tissues.
ISSN:1355-6037
1468-201X
DOI:10.1136/hrt.82.1.115