Adaptive mechanisms of arterial and venous coronary bypass grafts to an increase in flow demand

OBJECTIVE To compare the mechanisms by which arterial and venous grafts increase their flow during pacing induced tachycardia, early and later after coronary bypass surgery. DESIGN 43 grafts (13 epigastric artery, 15 mammary artery, 15 saphenous vein) evaluated early (9 (3) days (mean (SD)) after by...

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Bibliographic Details
Published in:Heart (British Cardiac Society) 1999-09, Vol.82 (3), p.336-342
Main Authors: Gurné, O, Chenu, P, Buche, M, Louagie, Y, Eucher, P, Marchandise, B, Rombaut, E, Blommaert, D, Schroeder, E
Format: Article
Language:English
Subjects:
Adaptation
Adaptation, Physiological
Aged
Automation
Biological and medical sciences
Blood Flow Velocity
Cardiac Pacing, Artificial
Catheters
Coronary Artery Bypass
coronary artery bypass graft
Coronary Circulation
Coronary vessels
Doppler effect
endothelial function
Endothelium, Vascular - physiopathology
Epigastric Arteries - transplantation
Female
Flow velocity
Follow-Up Studies
Heart rate
Heart surgery
Hemodynamics
Humans
Isosorbide Dinitrate
Male
Mammary Arteries - transplantation
Medical imaging
Medical sciences
Middle Aged
Postoperative Period
Saphenous Vein - transplantation
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Vasodilation
Vasodilator Agents
Veins & arteries
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Summary:OBJECTIVE To compare the mechanisms by which arterial and venous grafts increase their flow during pacing induced tachycardia, early and later after coronary bypass surgery. DESIGN 43 grafts (13 epigastric artery, 15 mammary artery, 15 saphenous vein) evaluated early (9 (3) days (mean (SD)) after bypass surgery were compared with 41 other grafts (15 epigastric, 11 mammary, 15 saphenous vein) evaluated later after surgery (mean 23 months, range 6 to 168 months) by quantitative angiography and intravascular Doppler velocity analysis during atrial pacing. Controls were 17 normal coronary arteries. RESULTS Baseline graft flow tended to be lower later after surgery than early (41 (16)v 45 (21) ml/min, NS). Blood flow increased during pacing by 30 (16)% early after surgery, less than later after surgery (+46 (18)%, p 
ISSN:1355-6037
1468-201X
DOI:10.1136/hrt.82.3.336