Loss of the normal coupling between the anaerobic threshold and insulin sensitivity in chronic heart failure

OBJECTIVE To explore whether the anaerobic threshold, a measure of the balance between aerobic and anaerobic cellular metabolism, is related to whole body insulin sensitivity in healthy individuals and in patients with chronic heart failure, which involves is an imbalance of aerobic and anaerobic me...

Full description

Saved in:
Bibliographic Details
Published in:Heart (British Cardiac Society) 1999-09, Vol.82 (3), p.348-351
Main Authors: Leyva, F, Chua, T-P, Godsland, I F, Coats, A J S, Anker, S D
Format: Article
Language:English
Subjects:
Aged
Anaerobic threshold
Anaerobic Threshold - physiology
Analysis of Variance
Biological and medical sciences
Blood pressure
Body fat
Body mass index
Cardiology. Vascular system
Cardiovascular disease
Case-Control Studies
Diuretics
Exercise
Exercise Test
Glucose
Glucose Tolerance Test
Heart
Heart failure
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Insulin resistance
Insulin Resistance - physiology
Medical sciences
Metabolism
Middle Aged
Physical fitness
Statistical analysis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:OBJECTIVE To explore whether the anaerobic threshold, a measure of the balance between aerobic and anaerobic cellular metabolism, is related to whole body insulin sensitivity in healthy individuals and in patients with chronic heart failure, which involves is an imbalance of aerobic and anaerobic metabolism. DESIGN Case–control study. SETTING A teaching hospital department specialising in heart failure. PATIENTS 20 healthy individuals (mean (SEM) age 55.2 (2.7) years) and 36 patients with chronic heart failure (59.1 (2.0) years, New York Heart Association class I–IV, anaerobic threshold 11.8 (0.7) ml/kg/min, left ventricular ejection fraction 26 (2)%). INTERVENTIONS An intravenous glucose tolerance test for assessment of insulin sensitivity (minimal model analysis) and a maximum treadmill exercise test for assessment of the anaerobic threshold, derived from measurement of oxygen consumption and carbon dioxide output. MAIN OUTCOME MEASURES Relation between insulin sensitivity and the anaerobic threshold in patients with chronic heart failure. RESULTS While anaerobic threshold was positively correlated with insulin sensitivity in healthy controls (r = 0.72, p 
ISSN:1355-6037
1468-201X
DOI:10.1136/hrt.82.3.348