Inappropriately low plasma leptin concentration in the cachexia associated with chronic heart failure

BACKGROUND Cardiac cachexia is a syndrome of generalised wasting which caries a poor prognosis and is associated with raised plasma concentrations of tumour necrosis factor α (TNFα). TNFα increases secretion of leptin, a hormone which decreases food intake and increases energy expenditure. OBJECTIVE...

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Bibliographic Details
Published in:Heart (British Cardiac Society) 1999-09, Vol.82 (3), p.352-356
Main Authors: Murdoch, D R, Rooney, E, Dargie, H J, Shapiro, D, Morton, J J, McMurray, J J V
Format: Article
Language:English
Subjects:
Adipose Tissue - pathology
Aged
Aged, 80 and over
Beta blockers
Biological and medical sciences
Biomarkers - blood
Body Mass Index
cachexia
Cachexia - blood
Cachexia - etiology
Cardiology. Vascular system
Cardiovascular disease
Case-Control Studies
Chronic Disease
cytokines
Female
Heart
heart failure
Heart Failure - blood
Heart Failure - complications
Heart Failure - pathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Hemodynamics
Humans
Leptin
Male
Medical sciences
Middle Aged
Norepinephrine - blood
Plasma
Proteins - metabolism
Quality of life
Retrospective Studies
Rodents
Severity of Illness Index
Tumor Necrosis Factor-alpha - metabolism
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Summary:BACKGROUND Cardiac cachexia is a syndrome of generalised wasting which caries a poor prognosis and is associated with raised plasma concentrations of tumour necrosis factor α (TNFα). TNFα increases secretion of leptin, a hormone which decreases food intake and increases energy expenditure. OBJECTIVE To determine whether an inappropriate increase in plasma leptin concentration contributes to the cachexia of chronic heart failure. DESIGN Retrospective case–control study. SETTING Tertiary referral cardiology unit. PATIENTS 110 human subjects comprising 29 cachectic chronic heart failure patients, 22 non-cachectic chronic heart failure patients, 33 patients with ischaemic heart disease but normal ventricular function, and 26 healthy controls. INTERVENTIONS Measurement of: body fat content by skinfold thickness (cachectic males
ISSN:1355-6037
1468-201X
DOI:10.1136/hrt.82.3.352