Interleukin 6 expression in coronary circulation after coronary angioplasty as a risk factor for restenosis

OBJECTIVE To investigate changes in cytokine expression in the coronary circulation induced by percutaneous transluminal coronary angioplasty (PTCA). METHODS The study involved 32 patients with ischaemic heart disease who underwent elective PTCA for isolated stenotic lesions of the left coronary art...

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Bibliographic Details
Published in:British heart journal 2000-07, Vol.84 (1), p.83-87
Main Authors: Hojo, Y, Ikeda, U, Katsuki, T, Mizuno, O, Fukazawa, H, Kurosaki, K, Fujikawa, H, Shimada, K
Format: Article
Language:English
Subjects:
Adult
Aged
Angina pectoris
Angioplasty
Angioplasty, Balloon, Coronary - adverse effects
Basic Research
Biological and medical sciences
Biomarkers - blood
Catheters
Coronary Angiography
Coronary Circulation
Coronary Disease - blood
Coronary Disease - diagnostic imaging
Coronary Disease - etiology
cytokine
Diseases of the cardiovascular system
Female
Follow-Up Studies
Heart attacks
Humans
inflammation
Interleukin-6 - blood
Male
Medical sciences
Middle Aged
Prognosis
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Recurrence
restenosis
Risk Factors
Rodents
Stents
Veins & arteries
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Summary:OBJECTIVE To investigate changes in cytokine expression in the coronary circulation induced by percutaneous transluminal coronary angioplasty (PTCA). METHODS The study involved 32 patients with ischaemic heart disease who underwent elective PTCA for isolated stenotic lesions of the left coronary artery. Ten patients had plain old balloon angioplasty, 10 had percutaneous transluminal rotational atherectomy, and 12 had stent implantation. Blood samples were drawn from the coronary sinus before and immediately after PTCA. Plasma concentrations of interleukin 6 (IL-6), platelet derived growth factor (PDGF), monocyte chemoattractant protein 1 (MCP-1), and macrophage coronary stimulating factor (M-CSF) were measured. The patients were scheduled for follow up angiography six months after PTCA. Late loss index was calculated using quantitative coronary angiography. RESULTS IL-6 concentrations in coronary sinus blood increased immediately after PTCA (p 
ISSN:1355-6037
0007-0769
1468-201X
DOI:10.1136/heart.84.1.83