Genetics of club foot in Maori and Pacific people

The role of major gene and multifactorial inheritance in the aetiology of club foot in the New Zealand Polynesian population was studied using 287 New Zealand Maori and Pacific club foot families. The club foot family data were analysed by complex segregation analysis under the mixed model using the...

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Bibliographic Details
Published in:Journal of medical genetics 2000-09, Vol.37 (9), p.680-683
Main Authors: Chapman, Cyril, Stott, N Susan, Port, Ramari Viola, Nicol, Richard O
Format: Article
Language:English
Subjects:
Alleles
Biological and medical sciences
club foot
Clubfoot - ethnology
Clubfoot - genetics
complex segregation analysis
Diseases of the osteoarticular system
Families & family life
Family Health
Female
Gene Frequency
Genetics
Hospitals
Humans
Male
Malformations and congenital and or hereditary diseases involving bones. Joint deformations
Medical records
Medical sciences
New Zealand - epidemiology
New Zealand Maori
Oral history
Original
Pedigree
Penetrance
Polynesia - ethnology
Population
Segregation
Studies
Tropical medicine
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Summary:The role of major gene and multifactorial inheritance in the aetiology of club foot in the New Zealand Polynesian population was studied using 287 New Zealand Maori and Pacific club foot families. The club foot family data were analysed by complex segregation analysis under the mixed model using the computer program POINTER. This analysis shows that the best genetic model for club foot in this population is a single dominant gene with a penetrance of 33% and a predicted gene frequency of 0.9%. These data provide a scientific foundation for molecular studies in the Maori and Polynesian population to identify putative club foot genes.
ISSN:0022-2593
1468-6244
1468-6244
DOI:10.1136/jmg.37.9.680