Genetic influences on the circulating cytokines involved in osteoclastogenesis

• Published in: Journal of medical genetics 2004-06, Vol.41 (6), p.e76-e76
• Main Authors: Livshits, G, Pantsulaia, I, Trofimov, S, Kobyliansky, E
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Carrier Proteins - blood; Cell Differentiation - genetics; Chromosomes; Cytokines; Cytokines - blood; Disease; Electronic Letter; Epidemiology; Female; Genes; Glycoproteins - blood; Growth hormones; heritability; HIV; Human immunodeficiency virus; Humans; Immune system; Ligands; M-CSF; Macrophage Colony-Stimulating Factor - blood; Male; Membrane Glycoproteins - blood; Metabolism; Metabolites; Middle Aged; model fitting; Models, Biological; Mortality; Multiple myeloma; Nuclear Family; Osteoclasts - cytology; Osteoclasts - metabolism; Osteogenesis - genetics; Osteoprotegerin; Pedigree; Quantitative genetics; RANK Ligand; RANKL; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear - blood; Receptors, Tumor Necrosis Factor; Sex Factors; Studies; Tumors; Womens health
• ISSN: 0022-2593; 1468-6244; 1468-6244
• DOI: 10.1136/jmg.2003.014373

The tumour necrosis factor family molecule RANKL (receptor activator of nuclear factor-kB ligand), its cellular receptor RANK, and the decoy receptor, osteoprotegerin (OPG) represent a novel cytokine triad with pleiotropic effects on bone metabolism, the immune system, and endocrine functions., RANKL is expressed on the osteoblast/stromal cell surface, binds to its receptor-RANK on the surface of haematopoietic precursor cells and, in the presence of macrophage colony stimulating factor (M-CSF), stimulates differentiation, fusion, activation, and survival of osteoclasts.). Subjects who participated in the study had no chronic or acute infection, haematological, metabolic, or other diseases, and no amenorrhoea; nor were they receiving prescription medication or steroidal anti-inflammatory drugs on a regular basis, nor consuming vitamin, mineral, or other dietary supplements. 19 Participants were unaware of the specific hypotheses tested, and signed a document of informed consent to the study, which was conducted with the approval of the Ethics Committee of Tel Aviv University.\n On the other hand, there is a growing body of evidence that the circulating levels of bone metabolites, including calciotropic hormones, some growth factors, and some cytokines, are determined to a considerable extent (between 30% and 80%) by genetic factors. 29, 30 The present study is the first comprehensively to quantify putative genetic and environmental effects on the plasma levels of M-CSF, OPG, and sRANKL.