Interaction between the α-T catenin gene (VR22) and APOE in Alzheimer’s disease

Background: APOE is the only gene that has been consistently replicated as a risk factor for late onset Alzheimer’s disease. Several recent studies have identified linkage to chromosome 10 for both risk and age of onset, suggesting that this region harbours genes that influence the development of th...

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Bibliographic Details
Published in:Journal of medical genetics 2005-10, Vol.42 (10), p.787-792
Main Authors: Martin, E R, Bronson, P G, Li, Y-J, Wall, N, Chung, R-H, Schmechel, D E, Small, G, Xu, P-T, Bartlett, J, Schnetz-Boutaud, N, Haines, J L, Gilbert, J R, Pericak-Vance, M A
Format: Article
Language:English
Subjects:
AAE
AAO
age at examination
age at onset
Aged
Aged, 80 and over
alpha Catenin - genetics
Alzheimer disease
Alzheimer Disease - genetics
APL
Apolipoproteins E - genetics
association in the presence of linkage
Biological and medical sciences
CAP
Cardiology. Vascular system
Collaborative Alzheimer Project
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
General aspects. Genetic counseling
genetic interaction
Genetic Predisposition to Disease
Hardy–Weinberg equilibrium
Humans
HWE
Indiana University Medical Center
Letter to JMG
Linkage Disequilibrium
Male
Medical genetics
Medical sciences
National Institutes of Mental Health
Neurology
NIMH
PDT
pedigree disequilibrium test
Polymorphism, Genetic
Polymorphism, Single Nucleotide
single nucleotide polymorphism
SNP
VR22
α-T catenin
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Summary:Background: APOE is the only gene that has been consistently replicated as a risk factor for late onset Alzheimer’s disease. Several recent studies have identified linkage to chromosome 10 for both risk and age of onset, suggesting that this region harbours genes that influence the development of the disease. A recent study reported association between single nucleotide polymorphisms (SNPs) in the VR22 gene (CTNNA3) on chromosome 10 and plasma levels of Aβ42, an endophenotype related to Alzheimer’s disease. Objective: To assess whether polymorphisms in the VR22 gene are associated with Alzheimer’s disease in a large sample of Alzheimer’s disease families and an independent set of unrelated cases and controls. Results: Several SNPs showed association in either the family based or case–control analyses (p
ISSN:0022-2593
1468-6244
DOI:10.1136/jmg.2004.029553