Prognostic factors in presurgical assessment of frontal lobe epilepsy

• Published in: Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1999-03, Vol.66 (3), p.350-356
• Main Authors: Ferrier, C H, Engelsman, J, Alarcón, G, Binnie, C D, Polkey, C E
• Format: Article
• Language: English
• Subjects: Adolescent; Age; Biological and medical sciences; Brain research; Child; Electroencephalography; Epilepsy; epilepsy surgery; Epilepsy, Frontal Lobe - physiopathology; Epilepsy, Frontal Lobe - psychology; Epilepsy, Frontal Lobe - surgery; Female; frontal lobe epilepsy; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Male; Medical imaging; Medical sciences; Nervous system (semeiology, syndromes); Neurology; Neuropsychological Tests; Neuropsychology; Pathology; Patients; presurgical assessment; Prognosis; Propagation; Retrospective Studies; Surgery; Surgical outcomes; Telemetry; Treatment Outcome
• ISSN: 0022-3050; 1468-330X
• DOI: 10.1136/jnnp.66.3.350

OBJECTIVES To determine predictors for surgical outcome in the presurgical assessment of frontal lobe epilepsy. METHODS Thirty seven patients were operated on for frontal lobe epilepsy between 1975 and 1996. Their medical records were reviewed for ictal semiology, age at onset, duration of the epilepsy, age at operation, preoperative interictal and ictal encephalographic findings, and abnormalities on neuroimaging and neuropsychological testing. In addition, type of resection and pathology were compared with surgical outcome. RESULTS Univariate statistical analysis showed that the presence of a focal abnormality on neuroimaging was associated with favourable outcome. The presence of the following ictal findings was associated with poor outcome: autonomic manifestations, eye deviation, head version contralateral to the operated side, and bilateral or multifocal ictal onset. Fifteen patients had secondarily generalised interictal discharges and, interestingly, their presence was not associated with poor outcome. Multivariate logistic regression showed that the presence of a focal abnormality on neuroimaging was significantly associated with a favourable outcome while contralateral head version was the only variable significantly associated with poor surgical outcome. CONCLUSIONS A focal abnormality on neuroimaging was the only variable which was significantly associated with a favourable surgical outcome, whereas contralateral head version was the most significant predictor for a poor outcome. The presence of generalised discharges before surgery was not associated with poor outcome.